Results 151 to 160 of about 386,943 (302)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Reproduction at the Margins: Migration and Legitimacy in the New Europe [PDF]
One of the most compelling demographic questions in contemporary Europe has been whether immigrant populations will bring their youthful age pyramids to help support Europe’s subfertile, aging populations.
FFF1Caroline H. NNN1Bledsoe
core
The impact of implementing the women's reproductive rights agenda on climate change. [PDF]
Front Glob Womens HealthTemmerman M +6 more
europepmc +1 more source
Ensuring the Reproductive Rights of Women with Intellectual Disability. [PDF]
J Intellect Dev Disabil, 2020 Agaronnik N +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source