Results 191 to 200 of about 587,241 (261)

Organ-on-a-Chip Models of the Female Reproductive System: Current Progress and Future Perspectives. [PDF]

Micromachines (Basel)
Pan M, Chen H, Deng K, Xiao K.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Diagnosis and treatment of 33 patients with primary melanoma of the female reproductive system. [PDF]

Front Oncol
Gao Y, Dong J, Chen L, Guo X, Liu L, Guo W, Ma C, Chen B, Wang J, Lv X.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review. [PDF]

Front Cell Dev Biol
Zhou Q, He M, Liu M, Sun G, Li J.
europepmc   +1 more source

Tryptophan-kynurenine pathway: a possible new mechanism for the prevention and treatment of reproductive system-related diseases. [PDF]

PeerJ
Ou Z, Xu A, Su H, Liu Y, Li J.
europepmc   +1 more source

The overlooked link between reproductive system disorders and depression: a cohort study in 2 million women. [PDF]

Psychol Med
Bliddal M, Wesselhoeft R, Rasmussen L, Janecka M, Zaks N, Petersen LK, Egsgaard S, Jensen PB, Munk-Olsen T.   +8 more
europepmc   +1 more source

Inflammation of the male reproductive system: clinical aspects and mechanisms. [PDF]

Front Endocrinol (Lausanne)
Bao B, Wen H, Wang F, Han D, Liu B.
europepmc   +1 more source

Risk factors and treatment strategies for female reproductive system carcinosarcoma with metastasis. [PDF]

Transl Cancer Res
Wu H, Huo P, Dong M, Xiao Y, Tu L.
europepmc   +1 more source

Advances in m6A Modification in Pregnancy-Related Disorders and Female Reproductive Endocrine Diseases. [PDF]

Expert Rev Mol Med
Dai F, Tao G, Zhang J, Deng Z, Yang D, Chen G, Sha Y, Yin T.   +7 more
europepmc   +1 more source