Results 131 to 140 of about 216,273 (311)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Working Motivation Sources and Related Factors of Embryologists
Fertility & ReproductionIntroduction: As the need for assisted reproductive technologies (ART) continues to grow, the workload for embryologists has significantly increased in recent years.
Nga T. T. Do +4 more
doaj +1 more source
The influence of expanded carrier screening in assisted reproductive techniques: changed the 'game'- review. [PDF]
Ann Med Surg (Lond), 2023 Drettas P +4 more
europepmc +1 more source
Assisted reproductive technology in reproductive medicine — possibilities and limitations
, 2016 Infertility has become an increasingly common health problem and has been estimated to affect approximately 10% of women in the reproductive age. Due to its high prevalence, it has been deemed a social disease by the World Health Organization (WHO).
Szamatowicz, Marian; Medical Institute PWSIiP in Lomza Department Reproductive Medicine and Gynecological Endocrinology MU in Białystok
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Perinatal Outcomes of Monochorionic Twin Pregnancies Conceived Naturally Versus through Assisted Reproductive Techniques. [PDF]
J Clin Med, 2023 Martínez-Varea A +5 more
europepmc +1 more source
2018 Assisted Reproductive Technology Fertility Clinic Success Rates Report [PDF]
The ART report provides an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics. It includes individual clinic tables with ART success rates for 456 fertility clinics in operation in 2018 that provided and ...
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source