Results 71 to 80 of about 475,651 (353)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Chromosomal Abnormalities in Iranian Infertile Males who are Candidates for Assisted Reproductive Techniques [PDF]

International Journal of Fertility and Sterility, 2007
Background: The present study offers our contribution on the topic by a retrospective analysis of the prevalence of chromosomal abnormalities in a population of Iranian infertile men attending assisted reproduction programs.Materials and Methods ...
iman salahshourifar, Mohammad Ali Sadighi Gilani, Najmeh sadat Masoudi, Hamid Gourabi   +3 more
doaj   +1 more source

The curse of Frankenstein: visions of technology and society in the debate over new reproductive technologies [PDF]

, 2003
At each successive moment in their development new reproductive technologies have provided the occasion for virulent argument about the role of technology in human affairs. And more generally, technoscientific knowledge has long been held both in awe and
Bloomfield, B P, Vurdubakis, T
core  

Computer-Generated Ovaries to Assist Follicle Counting Experiments [PDF]

, 2015
Precise estimation of the number of follicles in ovaries is of key importance in the field of reproductive biology, both from a developmental point of view, where follicle numbers are determined at specific time points, as well as from a therapeutic ...
A Gougeon, A Gougeon, AE Falender, Angelos Skodras, C Sforza, DC Sterio, GI Perez, Gianluca Marcelli, HJ Adèr, HJ Gundersen, J Canning, JB Kerr, JE Coxworth, JS Charleston, M Myers, Norbert Gleicher, P Da Silva-Buttkus, PB Hoyer, VC Howard   +18 more
core   +3 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Machine learning in predicting infertility treatment success: A systematic literature review of techniques

Journal of Education and Health Promotion
Assisted reproductive technology (ART) is one of the major developments that has had a significant impact on infertility treatment. A predictive model of ART success based on machine learning (ML) techniques can provide a robust basis for estimating ...
Shirin Dehghan, Hamid Moghaddasi, Reza Rabiei, Hamid Choobineh, Keivan Maghooli, Mojtaba Vahidi-Asl   +5 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Trends and factors associated with skilled birth attendance in a post-Ebola context: DHS Guinea 2018

Journal of Public Health in Africa
Background: In Guinea, the 2013–2015 Ebola epidemic profoundly affected maternal health service use. The frequency of births attended by skilled health professionals in the post-Ebola context remains under-documented.
Madeleine Toure, Fanta Barry, Tiany Sidibe, Sadan Camara, Ramata Diallo, Kaba Saran Keita, Maimouna Balde, Bienvenu Salim Camara, Karifa Kourouma, Mamadou Dioulde Balde   +9 more
doaj   +1 more source

Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report [PDF]

Iranian Journal of Medical Sciences
The incidence of ectopic pregnancy (EP) has increased in recent years, owing to causes such as pelvic inflammatory diseases and assisted reproductive technologies (ART).
Andrey Gaiday, Akylbek Tussupkaliyev, Abay Nurken, Assel Gaiday, Ainur Primbetova, Moldir Dossimbetova, Assemgul Yeszhanova, Bibigul Karimsakova, Nurgul Ablakimova   +8 more
doaj   +1 more source