Results 151 to 160 of about 223,319 (331)

Assessing Male Reproductive Toxicity during Drug Development

, 2017
Mário Sousa, Carolina Ferreira, Ana Rabaça, Rosália Sá   +3 more
openalex   +1 more source

Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period [PDF]

, 2018
A. K. Sai Siva Ram, K. Pratap Reddy, B. P. Girish, Ch. Supriya, P. Sreenivasula Reddy   +4 more
openalex   +1 more source

Reproductive and developmental toxicity screening test of new TiO2 GST in Sprague-Dawley rats [PDF]

, 2022
Hyung‐Seon Baek, Myeong-Kyu Park, Hye Min Kim, Jae Min Im, Heung-Sik Seo, Hee Ju Park, Sung Soon Nah   +6 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Inactivation of Mst/Nrf2/Keap1 signaling flexibly mitigates MAPK/NQO-HO1 activation in the reproductive axis of experimental fluorosis

Ecotoxicology and Environmental Safety
Fluoride induced reprotoxicity through oxidative stress-mediated reproductive cell death. Hence, the current study evaluated the importance of the MST/Nrf2/MAPK/NQO-HO1 signaling pathway in fluorosis-induced reproductive toxicity.
Mohammad Mehdi Ommati, Samira Sabouri, Zilong Sun, Mohammad Javad Zamiri, Socorro Retana‑Marquez, Hassan Nategh Ahmadi, Qiyong Zuo, Aziz Eftekhari, Lizbeth Juárez-Rojas, Yaser Asefi, Lina Lei, Shu-gang Cui, Mohammad Hasan Jadidi, Hong-wei Wang, Reza Heidari   +14 more
doaj   +1 more source

Selenium Nanoparticles And Silymarin To prevent Lead Acetate-Induced Toxicity On Reproductive Performance Of Male Rats

, 2020
Rasha Muzahem Hatem, Eman Mohammed Hussain   +1 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Alleviative Effects of Weizmannia coagulans CGMCC 9951 on the Reproductive Toxicity of Caenorhabditis elegans Induced by Polystyrene Microplastics

Microorganisms
The increased emission and accumulation of microplastics pose a severe threat to humans and the environment. As effective biological agents for alleviating the effects of microplastics, the mechanism of action of probiotics remains unclear. In this study,
Chengmei Li, Lina Zhao, Jiajia Fan, Wentong Qi, Xuan Li, Yuwan Li, Pingping Tian, Ying Wu, Shaobin Gu   +8 more
doaj   +1 more source