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A Scoping Review on Male-Mediated Developmental Toxicity [PDF]

Toxics
Background: Developmental toxicity is defined as adverse effects induced either during pregnancy or as a result of parental exposure. While considerable attention has been devoted to maternal exposure to such chemicals, the role of paternal exposure has ...
Lidia Caporossi, Paola Castellano, Enrico Paci, Daniela Pigini   +3 more
doaj   +2 more sources

Human developmental toxicity mechanism of polybrominated biphenyl exposure and health risk regulation strategy for special populations

Ecotoxicology and Environmental Safety, 2022
Polybrominated biphenyls (PBBs) can bioaccumulate in nature and are toxic to humans. Long-time exposure to PBBs in pregnant women can lead to the birth of an infant with abnormal conditions.
Luze Yang, Peixuan Sun, Wenjin Zhao, Miao Liu   +3 more
doaj   +1 more source

Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats

Toxics, 2023
The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by ...
Jimin Lee, Kangmin Kim, Seon-Mi Park, Jin-Sook Kwon, Eui-Bae Jeung   +4 more
doaj   +1 more source

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

Particle and Fibre Toxicology, 2020
Background Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life.
Battuja Batbajar Dugershaw, Leonie Aengenheister, Signe Schmidt Kjølner Hansen, Karin Sørig Hougaard, Tina Buerki-Thurnherr   +4 more
doaj   +1 more source

Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers

Journal of Ginseng Research, 2019
Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated.
Jinsoo Lee, Ji-Seong Jeong, Kyung-Jin Cho, Kyeong-Nang Moon, Sang Yun Kim, Byungcheol Han, Yong-Soon Kim, Eun Ju Jeong, Moon-Koo Chung, Wook-Joon Yu   +9 more
doaj   +1 more source

The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes

Current Research in Toxicology, 2020
devTOX quickPredict (devTOXqP) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity in vitro.
Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu, Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Lisa Maria Bode, Matthew Stevenson, Tanvir Walele   +10 more
doaj   +1 more source

Male-mediated developmental toxicity

Asian Journal of Andrology, 2014
Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children ...
Diana Anderson, Thomas E Schmid, Adolf Baumgartner   +2 more
doaj   +1 more source

In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact

Molecules, 2022
As the pharmacological properties and therapeutic applications of Cannabis sativa L. pace with the upsurge of interest of the scientific community in harnessing its constituent phytocannabinoids, illicit use may raise serious health issues ...
Theodoros Chatzimitakos, Ieremias Chousidis, Dimitrios Leonardos, Constantine Stalikas, Ioannis Leonardos   +4 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.
Barbara D. Abbott, Carmen R. Wood, Andrew M. Watkins, Kaberi P. Das, Christopher S. Lau   +4 more
doaj   +1 more source

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Toxics, 2022
With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema, Deborah L. Hunter, Bridgett N. Hill, Jeanene K. Olin, Katy N. Britton, Matthew R. Waalkes, Stephanie Padilla   +6 more
doaj   +1 more source