Results 31 to 40 of about 2,744,821 (349)
Advanced human developmental toxicity and teratogenicity assessment using human organoid models.
Ecotoxicology and Environmental Safety, 2022 Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo ...
Minghui Li +5 more
semanticscholar +1 more source
Cardiac developmental toxicity [PDF]
Birth Defects Research Part C: Embryo Today: Reviews, 2011 AbstractCongenital heart disease (CHD) is a highly prevalent problem with mostly unknown origins. Many cases of CHD likely involve an environmental exposure coupled with genetic susceptibility, but practical and ethical considerations make nongenetic causes of CHD difficult to assess in humans.
Gretchen J, Mahler, Jonathan T, Butcher
openaire +2 more sources
Engineering spatial-organized cardiac organoids for developmental toxicity testing
Stem Cell Reports, 2021 Summary Emerging technologies in stem cell engineering have produced sophisticated organoid platforms by controlling stem cell fate via biomaterial instructive cues. By micropatterning and differentiating human induced pluripotent stem cells (hiPSCs), we
Plansky Hoang +11 more
semanticscholar +1 more source
Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity
iScience, 2022 Summary Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in environmental and biological samples and cause adverse health effects.
Yvonne Rericha +5 more
semanticscholar +1 more source
Male-Mediated Developmental Toxicity [PDF]
Annual Review of Public Health, 1993 The etiology of many of the adverse reproductive outcomes among humans is not well understood. Most epidemiologic and laboratory research focuses on maternal factors. Studies of such adverse developmental outcomes as spontaneous abortion, low birthweight, and birth defects have assessed maternal drug, smoking, alcohol, infectious, and occupational ...
A F, Olshan, E M, Faustman
openaire +2 more sources
Developmental toxicity of cadmium in infants and children: a review
Environmental Analysis Health and Toxicology, 2021 Several millions of people are exposed to cadmium worldwide due to natural and anthropogenic activities that led to their widespread distribution in the environment and have shown potential adverse effects on the kidneys, liver, heart and nervous system.
Lalit P. Chandravanshi +2 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 The zebrafish as an alternative animal model for developmental toxicity testing has been extensively investigated, but its assay protocol was not harmonized yet. This study has validated and optimized the zebrafish developmental toxicity assay previously
Yi-Sheng Song +10 more
semanticscholar +1 more source
Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]
, 2006 Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Cadot, R. +6 more
core +1 more source
Current Research in Toxicology, 2020 devTOX quickPredict (devTOXqP) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity in vitro.
Liam Simms +10 more
doaj +1 more source
Environmental Health Perspectives, 2020 Background: Per- and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is associated with developmental toxicity, prompting their replacement with short ...
Shaza Gaballah +9 more
semanticscholar +1 more source