Results 11 to 20 of about 2,744,821 (349)
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials [PDF]
Particle and Fibre Toxicology, 2020 Background Epidemiological and animal studies provide compelling indications that environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal development and offspring health later in life.
Battuja Batbajar Dugershaw +4 more
doaj +3 more sources
CAESAR models for developmental toxicity [PDF]
Chemistry Central Journal, 2010 Background The new REACH legislation requires assessment of a large number of chemicals in the European market for several endpoints. Developmental toxicity is one of the most difficult endpoints to assess, on account of the complexity, length and costs ...
Piclin Nadège +7 more
doaj +4 more sources
A Scoping Review on Male-Mediated Developmental Toxicity [PDF]
ToxicsBackground: Developmental toxicity is defined as adverse effects induced either during pregnancy or as a result of parental exposure. While considerable attention has been devoted to maternal exposure to such chemicals, the role of paternal exposure has ...
Lidia Caporossi +3 more
doaj +3 more sources
Toxics, 2022 With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays.
Kimberly A. Jarema +6 more
doaj +2 more sources
Frontiers in Toxicology, 2021 Dimethyl sulfoxide (DMSO) is a popular solvent for developmental toxicity testing of chemicals and pharmaceuticals in zebrafish embryos. In general, it is recommended to keep the final DMSO concentration as low as possible for zebrafish embryos ...
Jente Hoyberghs +2 more
exaly +2 more sources
Environmental Science & Technology, 2022 For hazard identification and classification and labeling purposes, animal testing guidelines are required by law to evaluate developmental toxicity for new and existing chemical products.
Heather L Ciallella +2 more
exaly +2 more sources
Developmental toxicity of glyphosate on embryo-larval zebrafish (Danio rerio)
Ecotoxicology and Environmental Safety, 2022 Glyphosate (GLY) induces developmental toxicity in fish, but research on the toxicity mechanism is limited. In this study, zebrafish embryos were exposed for 120 hpf to 0.7, 7, and 35 mg L-1 GLY.
Yousef Sultân, Yiyi Feng, Junguo Ma
exaly +2 more sources
The problem of maternal toxicity in developmental toxicity studies [PDF]
Regulatory Toxicology and Pharmacology, 2012 Guidelines for developmental toxicity studies require that the highest dose(s) should induce some signs of maternal toxicity. However, the interpretation of the results is often difficult when developmentally toxic effects are recorded only at maternotoxic doses, as it is impossible to ascertain whether the developmental effects are maternally mediated
Erminio, Giavini, Elena, Menegola
openaire +4 more sources
Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)
ToxicsPer- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS
Katy N. Britton +9 more
doaj +2 more sources
Building a developmental toxicity ontology [PDF]
Birth Defects Research, 2018 BackgroundAs more information is generated about modes of action for developmental toxicity and more data are generated using high‐throughput and high‐content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology ...
Nancy Baker +11 more
openaire +7 more sources