Results 11 to 20 of about 130,891 (267)
CAESAR models for developmental toxicity [PDF]
Chemistry Central Journal, 2010 Background The new REACH legislation requires assessment of a large number of chemicals in the European market for several endpoints. Developmental toxicity is one of the most difficult endpoints to assess, on account of the complexity, length and costs ...
Piclin Nadège +7 more
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Cardiac developmental toxicity [PDF]
Birth Defects Research Part C: Embryo Today: Reviews, 2011 AbstractCongenital heart disease (CHD) is a highly prevalent problem with mostly unknown origins. Many cases of CHD likely involve an environmental exposure coupled with genetic susceptibility, but practical and ethical considerations make nongenetic causes of CHD difficult to assess in humans.
Gretchen J, Mahler, Jonathan T, Butcher
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Male-Mediated Developmental Toxicity [PDF]
Annual Review of Public Health, 1993 The etiology of many of the adverse reproductive outcomes among humans is not well understood. Most epidemiologic and laboratory research focuses on maternal factors. Studies of such adverse developmental outcomes as spontaneous abortion, low birthweight, and birth defects have assessed maternal drug, smoking, alcohol, infectious, and occupational ...
A F, Olshan, E M, Faustman
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The problem of maternal toxicity in developmental toxicity studies [PDF]
Regulatory Toxicology and Pharmacology, 2012 Guidelines for developmental toxicity studies require that the highest dose(s) should induce some signs of maternal toxicity. However, the interpretation of the results is often difficult when developmentally toxic effects are recorded only at maternotoxic doses, as it is impossible to ascertain whether the developmental effects are maternally mediated
Erminio, Giavini, Elena, Menegola
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Building a developmental toxicity ontology [PDF]
Birth Defects Research, 2018 BackgroundAs more information is generated about modes of action for developmental toxicity and more data are generated using high‐throughput and high‐content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology ...
Nancy Baker +11 more
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Particle and Fibre Toxicology, 2020 Background Silver nanoparticles (AgNPs) are used extensively in various consumer products because of their antimicrobial potential. This requires insight in their potential hazards and risks including adverse effects during pregnancy on the developing ...
Ashraf Abdelkhaliq +3 more
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Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Biological Research, 2023 Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause intrauterine growth retardation (IUGR) and multi-organ developmental toxicity in offspring, and susceptibility
Liang Liu +4 more
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Developmental toxicity of Zishen Guchong Pill on the early life stages of Zebrafish
Phytomedicine Plus, 2021 Background: Zishen Guchong Pill (ZGP), a traditional oriental herbal medicine, has been applied broadly in the treatment of threatened or recurrent miscarriages in clinics, but little is known about its developmental toxicity.Aim of the study: This study
Jiazhen Wang +10 more
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Ecotoxicology and Environmental Safety, 2022 Bromoacetamide (BAcAm) is a nitrogenous disinfection by-product. We previously found that BAcAm induced developmental toxicity in zebrafish embryos, but the underlying mechanisms remain to be elucidated.
Wei Wang +8 more
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Emerging exposures of developmental toxicants [PDF]
Current Opinion in Pediatrics, 2017 Purpose of review The purpose of this review is to identify emerging developmental toxicants that are understudied in children's health. Exposures may arise from new products designed to improve utility, to reduce toxicity, or to replace undesirable chemicals.
Mary S, Wolff +4 more
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