Results 41 to 50 of about 130,891 (267)

Toxicokinetics of a developmental toxicity test in zebrafish embryos and larvae: Relationship with drug exposure in humans and other mammals

Current Research in Toxicology
To study the effects of drugs on embryo/fetal development (EFD), developmental and reproductive toxicity studies in zebrafish (Danio rerio) embryos is expected to be an accepted alternative method to animal studies using mammals. However, there is a lack
Tasuku Nawaji, Naohiro Mizoguchi, Ryuta Adachi, Hiroki Teraoka   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Developmental toxicity of organotin compounds in animals

Frontiers in Marine Science, 2014
Organotin compounds (OTs) have been used as biocides in antifouling paints and agriculture. The IMO introduced a global ban on the use of OTs in antifouling systems in 2001 due to their high toxicity.
Lijiao eWu, Zhenhuang eChen, Jingmin eZhu, Lingling eHu, Xiao eHUANG, Huahong eShi   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)

Toxics
Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS
Katy N. Britton, Richard S. Judson, Bridgett N. Hill, Kimberly A. Jarema, Jeanene K. Olin, Bridget R. Knapp, Morgan Lowery, Madison Feshuk, Jason Brown, Stephanie Padilla   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrative network toxicology, multiomics, and machine learning elucidate zearalenone-induced developmental toxicity mechanisms in zebrafish (Danio rerio)

Ecotoxicology and Environmental Safety
Zearalenone (ZEN) is a naturally occurring environmental contaminant that is produced by fungi. Developing animals are particularly sensitive to ZEN, while the mechanisms underlying ZEN-induced developmental toxicity remain incompletely understood ...
Bingxuan Jia, Huikang Lin, Yingzhu Tan, Aibo Wu   +3 more
doaj   +1 more source

DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

Frontiers in Pharmacology, 2016
Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal death.
Yuhei eNishimura, Shota eSasagawa, Tetsuo eKon, Yukiko eYamanaka, Soichiro eMurakami, Yoshifumi eAshikawa, Mizuki eYuge, Shiko eOkabe, Koki eKawaguchi, Reiko eKawase, TOSHIO eTANAKA   +10 more
doaj   +1 more source