Results 41 to 50 of about 2,744,821 (349)

Fluorotelomer ethoxylates cause developmental toxicity in mice

, 2023
Poly- and perfluoroalkyl substances are a ubiquitous class of compounds which are considered persistent organic pollutants. Many of these compounds are unregulated and understudied but are still widely used. One group of these compounds are fluorotelomer
Nikita, Harvey, Jenna, Hanrahan, Lindsay, Cahill, Karl, Jobst, Katherine, Steeves   +4 more
core   +1 more source

Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers

Journal of Ginseng Research, 2019
Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated.
Jinsoo Lee, Ji-Seong Jeong, Kyung-Jin Cho, Kyeong-Nang Moon, Sang Yun Kim, Byungcheol Han, Yong-Soon Kim, Eun Ju Jeong, Moon-Koo Chung, Wook-Joon Yu   +9 more
doaj   +1 more source

In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact

Molecules, 2022
As the pharmacological properties and therapeutic applications of Cannabis sativa L. pace with the upsurge of interest of the scientific community in harnessing its constituent phytocannabinoids, illicit use may raise serious health issues ...
Theodoros Chatzimitakos, Ieremias Chousidis, Dimitrios Leonardos, Constantine Stalikas, Ioannis Leonardos   +4 more
doaj   +1 more source

Male-mediated developmental toxicity

Asian Journal of Andrology, 2014
Male-mediated developmental toxicity has been of concern for many years. The public became aware of male-mediated developmental toxicity in the early 1990s when it was reported that men working at Sellafield might be causing leukemia in their children ...
Diana Anderson, Thomas E Schmid, Adolf Baumgartner   +2 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptors Alpha, Beta, and Gamma mRNA and Protein Expression in Human Fetal Tissues

PPAR Research, 2010
Peroxisome proliferator-activated receptors (PPARs) regulate lipid and glucose homeostasis, are targets of pharmaceuticals, and are also activated by environmental contaminants.
Barbara D. Abbott, Carmen R. Wood, Andrew M. Watkins, Kaberi P. Das, Christopher S. Lau   +4 more
doaj   +1 more source

Embryo-fetal developmental toxicity study design for pharmaceuticals

, 2022
S.418-428Assessment of potential developmental and reproductive toxicity of human pharmaceuticals is currently guided by the International Conference on Harmonization (ICH) S5(R2) document (available at http://www.ich.org).
Lerman, S.A., Fisher, J.E., Stump, D.G., Wise, L.D., Feuston, M.H., Ooshima, Y., Buschmann, J., Hoberman, A.M., Hew, K.W.   +8 more
core   +1 more source

Microplastics enhance the developmental toxicity of synthetic phenolic antioxidants by disturbing the thyroid function and metabolism in developing zebrafish.

Environment International, 2020
Coexposure of MPs and other contaminants adsorbed from the environment has raised many attentions, but the understanding of the combined effects of MPs and plastic additives are limited.
Huajin Zhao, Jiankang Xu, Zehua Yan, H. Ren, Yan Zhang   +4 more
semanticscholar   +1 more source

Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming

Biological Research, 2023
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause intrauterine growth retardation (IUGR) and multi-organ developmental toxicity in offspring, and susceptibility
Liang Liu, Yinxian Wen, Qubo Ni, Liaobin Chen, Hui Wang   +4 more
doaj   +1 more source

Developmental toxicity of bromoacetamide via the thyroid hormone receptors-mediated disruption of thyroid hormone homeostasis in zebrafish embryos

Ecotoxicology and Environmental Safety, 2022
Bromoacetamide (BAcAm) is a nitrogenous disinfection by-product. We previously found that BAcAm induced developmental toxicity in zebrafish embryos, but the underlying mechanisms remain to be elucidated.
Wei Wang, Qiyao Ma, Xinliang Ding, Yihua Xu, Mengting He, Jie Xu, Jianjun Liu, Cheng Ji, Jie Zhang   +8 more
doaj   +1 more source

Developmental toxicity of Zishen Guchong Pill on the early life stages of Zebrafish

Phytomedicine Plus, 2021
Background: Zishen Guchong Pill (ZGP), a traditional oriental herbal medicine, has been applied broadly in the treatment of threatened or recurrent miscarriages in clinics, but little is known about its developmental toxicity.Aim of the study: This study
Jiazhen Wang, Cailian Mo, Pengfei Tu, Na Ning, Xin Liu, Shenghua Lin, Sellamani Muthulakshmi, Zixin He, Yun Zhang, Kechun Liu, Qiuxia He   +10 more
doaj   +1 more source