Results 61 to 70 of about 2,744,821 (349)

Developmental toxicity of plastic leachates on the sea urchin Paracentrotus lividus.

Environmental Pollution, 2020
Microplastic pollution has become ubiquitous, affecting a wide variety of biota. Although microplastics are known to alter the development of a range of marine invertebrates, no studies provide a detailed morphological characterisation of the ...
F. Rendell-Bhatti, Periklis Paganos, A. Pouch, C. Mitchell, S. D’Aniello, B. Godley, K. Pazdro, M. Arnone, Eva Jiménez-Guri   +8 more
semanticscholar   +1 more source

Neurobehavioural effects of developmental toxicity

Lancet Neurology, 2014
Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in frequency.
P. Grandjean, P. Landrigan
semanticscholar   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients

Stem Cell Research
Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient ...
Xuan Xu, Bing Xue, Dingqi Zhang, Yupeng Wang, Bonan Chen, Zhenghua Shan, Wenzhuo Zhao, Tianxiao Qiu, Jing Sun, Shengying Qin   +9 more
doaj   +1 more source

Safety profile of 40% Garcinol from Garcinia indica in experimental rodents

Toxicology Reports, 2018
The present study was taken up to evaluate the single dose acute toxicity, 28 days and 90 days repeated dose toxicity and reproductive/developmental toxicity of standardized 40% Garcinol in experimental rodents.
Muhammed Majeed, Sarang Bani, Beena Bhat, Anjali Pandey, Lakshmi Mundkur, Prakriti Neupane   +5 more
doaj   +1 more source

Prophylactic efficacy of Boerhavia diffusa L. aqueous extract in toluene induced reproductive and developmental toxicity in Drosophila melanogaster

Journal of Infection and Public Health, 2020
Background: Environmental exposure to toxicants poses high risk to develop reproductive and developmental chronic toxicity in man. Toluene is one of the commonest industrial agents whose exposure is attributed with potential to induce reproductive and ...
Benil PB, Sreeja Rani, Young Ock Kim, Abdullah Ahmed Al-Ghamdi, Mohamed S. Elshikh, Monerah A. Al-Dosary, Ashraf A. Hatamleh, Selvaraj Arokiyaraj, Hak-Jae Kim   +8 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Profiling the ToxCast library with a pluripotent human (H9) stem cell line-based biomarker assay for developmental toxicity.

Toxicological Sciences, 2020
The Stemina devTOX quickPredict platform (devTOXqP) is a human pluripotent stem cell-based assay that predicts the developmental toxicity potential based on changes in cellular metabolism following chemical exposure [Palmer et al. 2013]. Using this assay,
Todd J. Zurlinden, Katerine S. Saili, Nathaniel Rush, P. Kothiya, R. Judson, K. Houck, E. Hunter, Nancy C. Baker, J. Palmer, Russell S. Thomas, Thomas B Knudsen   +10 more
semanticscholar   +1 more source

Pre- and postnatal developmental toxicity study design for pharmaceuticals

, 2022
S.437-445Assessment of potential developmental and reproductive toxicity of human pharmaceuticals is currently guided by the ICH S5(R2) document. The studies that assess the hazard of both pre- and postnatal exposure are predominantly conducted in ...
Hurtt, M., Fisher, J.E., Wise, L.D., Bailey, G.P., Buschmann, J.   +4 more
core   +1 more source

The toxicity of perfluoroalkyl acids in zebrafish (Danio rerio) [PDF]

, 2013
Perfluoroalkyl acids (PFAAs) are globally distributed synthetic chemicals. Their unique properties make them widely used, in industry and elsewhere. These are a group of compounds with varying carbon chain lengths and functional groups.
Ul Haq, Mazhar
core