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Biomarkers of reproductive toxicity

Cancer Biomarkers, 2005
A biomarker can be broadly defined as any biological index capable of being measured, which is associated with or indicative of a defined biological endpoint such as a developmental or disease stage. Identification and verification of anatomical, endocrine, cellular and molecular biomarkers is crucial for successful clinical diagnosis and treatment of ...
John C, Rockett, Sung J, Kim
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Toxicity Testing, Reproductive

2005
Abstract Reproductive toxicity evaluations encompass embryo/fetal development in utero, secondary and tertiary sex characteristics, sexual behavior and performance in both sexes, and pregnancy, parturition, lactation, and other maternal behaviors in females.
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Reproductive Toxicity: Hypothalamic‐Pituitary Mechanisms

American Journal of Industrial Medicine, 1983
The hypothalamic‐pituitary axis serves as the primary control center for reproductive hormones. Several agents can inhibit this control center and thereby disrupt reproductive function. Of major interest among these agents are the neuropharmacologic drugs that alter the central rervous system input to the hypothalamus.
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Reproductive toxicity of phthalate esters

Molecular Nutrition & Food Research, 2010
AbstractPhthalate esters are ubiquitous environmental contaminants that in general display low‐toxicity. Overall, the reproductive effects of these compounds are well characterized in adult's animals, with gonadal injury observed after high dose exposure.
Anderson Joel, Martino-Andrade   +1 more
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REPRODUCTIVE TOXICITY OF THE PSORALENS

Pediatric Pathology & Molecular Medicine, 2003
The psoralens are naturally occurring secondary metabolites in plants, including many fruits and vegetables. Health risks have been associated with handling or ingesting psoralen-containing plants, and with the use of synthetic psoralens in photochemotherapy of skin disorders. Our research has demonstrated that administration of the psoralens bergapten
Moussa M, Diawara, Paul J, Kulkosky
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Reproductive toxicity testing of vaccines

Toxicology, 2003
Vaccines play a major role in the prevention of human birth defects by protecting the pregnant woman from teratogenic or otherwise harmful infections. Until now, it has not been common practice to perform preclinical developmental toxicity tests for new vaccines. Despite the excellent safety record of vaccines, increased attention is now being given to
François, Verdier   +2 more
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