Results 41 to 50 of about 4,196,973 (344)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Estado, justiça e reconhecimento State, justice, and recognition
Análise Social, 2010 Este artigo investiga, a partir de uma crítica normativa, a perspectiva liberal e a perspectiva comunitarista do conceito de justiça, com o objectivo de reflectir sobre o papel do Estado nas democracias contemporâneas.
Fernando Filgueiras
doaj
, 2019 This book is a lucid and accessible companion to Plato’s Republic, throwing light upon the text’s arguments and main themes, placing them in the wider context of the text’s structure. In its illumination of the philosophical ideas underpinning the work, it provides readers with an understanding and appreciation of the complexity and literary artistry ...
openaire +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Guideline for handling pesticide residues in Czech organic production [PDF]
, 2013 This document was prepared in the project «Development of guidelines for the use of pesticide analysis in organic inspection in the Czech Republic (sampling, evaluation and interpretation)». At the beginning of this project, a workshop with stakeholders
Bickel, Regula +3 more
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
The Structure of Consumer Basket in the Czech Republic and Slovak Republic [PDF]
, 2014 Purpose of the article: Nowadays, consumer behaviour is still at the centre of attention of many researchers. The consumer basket belongs among important economic characteristics, which determine the economic level of each country.
Gottwald, Radim
core
Nuevo mundo - Mundos Nuevos, 2014 This paper explores, from a transnational perspective, the relation between war of independence and the construction of citizenship in territories belonging to Peru, Bolivia and the Northwest of Argentina.
Ana María Lorandi
doaj +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Church and State in Lithuania, Latvia and Estonia [PDF]
, 1976 Glimpses of the Baltic ...
Moellering, Ralph L.
core +1 more source