Results 1 to 10 of about 139,836 (280)

Does collective consciousness compromise during epidemics and pandemics? [PDF]

EAI Endorsed Transactions on Smart Cities, 2021
The ongoing pandemic, COVID-19, has received unprecedented global attention. Though a pathogen is essentially the causative agent, the dynamics of the cause-effect in major events like the ongoing COVID-19 pandemic is not ...
Anoushka Khanna, Namita I, Rina Chakrabarti, Prem Indraganti   +3 more
doaj   +1 more source

Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice

Pharmaceuticals, 2023
Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients.
Mirjana Radovanovic, Peter Galettis, Alex Flynn, Jennifer H. Martin, Jennifer J. Schneider   +4 more
doaj   +1 more source

Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment

Cells, 2022
Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage.
Mathew Lozinski, Nikola A. Bowden, Moira C. Graves, Michael Fay, Bryan W. Day, Brett W. Stringer, Paul A. Tooney   +6 more
doaj   +1 more source

A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools

Critical Care Explorations, 2023
COVID-19 highlighted the need for use of real-world data (RWD) in critical care as a near real-time resource for clinical, research, and policy efforts.
Smith F. Heavner, PhD, RN, Wesley Anderson, PhD, Rahul Kashyap, MBBS, MBA, Pamela Dasher, BA, Ewy A. Mathé, PhD, Laura Merson, Philippe J. Guerin, MD, PhD, Jeff Weaver, MBA, Matthew Robinson, MD, Marco Schito, PhD, Vishakha K. Kumar, MD, MBA, Paul Nagy, PhD   +11 more
doaj   +1 more source

Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy

BMC Cancer, 2022
Background Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC.
Michelle W. Wong-Brown, Andre van der Westhuizen, Nikola A. Bowden   +2 more
doaj   +1 more source

Overall survival in metastatic melanoma correlates with pembrolizumab exposure and T cell exhaustion markers

Pharmacology Research & Perspectives, 2021
Trial data support an absence of an exposure–survival relationship for pembrolizumab. As these relationships remain unexamined in a real‐world setting, we determined them in metastatic melanoma prospectively in an observational study.
Vishal Navani, Moira C. Graves, Giovana Celli Marchett, Hiren Mandaliya, Nikola A. Bowden, Andre van derWesthuizen   +5 more
doaj   +1 more source

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening

Membranes, 2022
Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca2+-permeable ion channel with multimodal gating which can be activated by low temperatures and cooling compounds, such as menthol and icilin.
Farhad Jahanfar, Laura Sadofsky, Alyn Morice, Massimo D’Amico   +3 more
doaj   +1 more source

Antifungal Drug Repurposing [PDF]

Antibiotics, 2020
Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including the generation of reactive oxygen species.
Jong H. Kim, Luisa W. Cheng, Kathleen L. Chan, Christina C. Tam, Noreen Mahoney, Mendel Friedman, Mikhail Martchenko Shilman, Kirkwood M. Land   +7 more
openaire   +3 more sources

Repurposing of the Tamoxifen Metabolites to Treat Methicillin-Resistant Staphylococcus epidermidis and Vancomycin-Resistant Enterococcus faecalis Infections

Microbiology Spectrum, 2021
Repurposing drugs provides a new approach to the fight against multidrug-resistant (MDR) bacteria. We have reported that three major tamoxifen metabolites, N-desmethyltamoxifen (DTAM), 4-hydroxytamoxifen (HTAM), and endoxifen (ENDX), presented ...
Andrea Miró-Canturri, Andrea Vila-Domínguez, Marta Caretero-Ledesma, Rafael Ayerbe-Algaba, Jerónimo Pachón, Manuel Enrique Jiménez-Mejías, Younes Smani   +6 more
doaj   +1 more source

Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease

Frontiers in Human Neuroscience, 2021
Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson’s disease. In this review, we summarise the recent insights into freezing of gait and highlight the strategies that should be considered to improve future treatment.
Cathy K. Cui, Simon J. G. Lewis
doaj   +1 more source