Results 101 to 110 of about 139,836 (280)

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Charge Transfer States in Donor–Acceptor Bulk‐Heterojunctions as Triplet–Triplet Annihilation Sensitizer for Solid‐State Photon Upconversion

Advanced Materials Interfaces, EarlyView.
A near‐infrared photosensitizer that facilitates efficient solid‐state photon upconversion by recycling triplets formed within a fullerene‐based donor–acceptor bulk‐heterojunction system is demonstrated. Spectroscopic investigations reveal that the energy of photogenerated charge transfer states of triplet character (3CT) is subsequently transferred to
Maciej Klein, Alexander R. Ireland, Evan G. Moore, Dennis Delic, Ajay K. Pandey   +4 more
wiley   +1 more source

UBC4: A Repurposed Drug Regimen for Adjunctive Use During Bladder Cancer Treatment

Biomedicines
After it has metastasized, bladder cancer, the malignant transformation of the bladder urothelium, continues to be a common cause of death after maximal use of all currently available standard treatments.
Richard E. Kast
doaj   +1 more source

Recent Advances on Thermochromic Inks for Security Applications

Advanced Materials Technologies, EarlyView.
Thermochromic security inks have garnered interest in recent years as security elements for authentication, information encryption, and anti‐counterfeiting. This review outlines different types of thermochromic materials, how they have been developed as functional inks, and how advancements in property enhancement, sustainability, and printing ...
Duarte B. Oliveira, Andreia Araújo, Elvira Fortunato, Rodrigo Martins, Marta C. Corvo, Emanuel Carlos   +5 more
wiley   +1 more source

Open Source Repurposing Reveals Broad-Spectrum Antiviral Activity of Diphenylureas

Viruses
The pandemic threat from newly emerging viral diseases constitutes a major unsolved issue for global health. Antiviral therapy can play an important role in treating and preventing the spread of unprecedented viral infections.
Ulrich A. K. Betz, Robert Garces, Norbert Beier, Sven Lindemann, Karen C. Wolff, Laura Riva, Melanie G. Kirkpatrick, Amal Gebara-Lamb, Case W. McNamara, Robert Damoiseaux, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Mårten Strand, Yongdae Gwon, Mikael Elofsson, Magnus Evander   +15 more
doaj   +1 more source

Degradable Magnetic Composites from Recycled NdFeB Magnets for Soft Actuation and Sensing

Advanced Robotics Research, EarlyView.
This work presents a degradable soft magnetic composite made from recycled NdFeB particles embedded in a gelatin‐based organogel. The material is processed into magnetic sensors and soft robotic components, which can later be dissolved in a green solvent to recover NdFeB magnetic particles.
Muhammad Bilal Khan, Lin Guo, Kilian Schäfer, Eduardo Sergio Oliveros‐Mata, Xiaotao Wang, Florian Hofmann, Matthias Lutzi, Mark Suppelt, Proloy Taran Das, Jan Schmidtpeter, Imants Dirba, Stephan Rinderknecht, Mario Kupnik, Denys Makarov, Oliver Gutfleisch   +14 more
wiley   +1 more source

Gait Analysis of Pak Biawak: A Necrobot Lizard Built using the Skeleton of an Asian Water Monitor (Varanus Salvator)

Advanced Robotics Research, EarlyView.
Pak Biawak, a necrobot, embodies an unusual fusion of biology and robotics. Designed to repurpose natural structures after death, it challenges conventional boundaries between nature and engineering. Its movements are precise yet unsettling, raising questions about sustainability, ethics, and the untapped potential of biointegrated machines.
Leo Foulds, Donan Satria Yudha, Parvez Alam   +2 more
wiley   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]

, 2014
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano, Talevi, Alan   +1 more
core   +1 more source

Ecosystem‐Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs)

Advanced Science, EarlyView.
Robots exploring natural ecosystems can support monitoring and conservation, but must adopt ecosystem‐centered design to avoid pollution, waste, and damage. This review proposes guidelines for co‐designing ecoresorbable sustainability robots (ESRs), uniting materials, robotics, and ecological contexts in a single framework.
Tülin Yılmaz Nayır, Yuan Fang, Consuelo Contreras, Andrew K. Schulz, Florian Hartmann   +4 more
wiley   +1 more source