Results 171 to 180 of about 139,836 (280)

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Correction: Editorial: Opportunities and challenges in drug repurposing. [PDF]

Front Pharmacol
Camps I, Künzel SR, Schubert M, Singh RK.   +3 more
europepmc   +1 more source

Repurposing ceritinib [PDF]

Nature Reviews Drug Discovery, 2017
openaire   +1 more source

Thermoelectric Property Mapping for High‐Performance Integrated MgAgSb‐MgCuSb System

Advanced Science, EarlyView.
From the property mapping of the MgAgSb–MgCuSb system, both thermoelectric materials and corresponding interface materials are optimized: Ag‐rich compositions provide higher PF and zT, whereas Cu‐rich side yields superior transport properties and low contact resistance.
Jiankang Li, Airan Li, Longquan Wang, Xinzhi Wu, Raju Chetty, Takao Mori   +5 more
wiley   +1 more source

An evaluation of Roluperidone as a promising repurposing candidate for Alzheimer's Disease: A Computational Investigation. [PDF]

PLoS One
Tanjin R, Al-Amin M, Etee JM, Siddika A, Siddiki A, Mahi SI, Toma SN, Akter N, Uddin MH, Bristy NA, Mowlee SI, Rafa EK, Hossen MF.   +12 more
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Drug Repurposing for Inclusion of COVID-19-Related Indication: Field Study of the European Medicines Agency's Response to the Pandemic. [PDF]

Pharmacy (Basel)
Ivanov A, Getova-Kolarova V, Hababa-Ivanova I.   +2 more
europepmc   +1 more source

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Correction: A bibliometric analysis and systematic review of drug repurposing against drug-resistant ESKAPE pathogens: a particular focus on <i>Pseudomonas aeruginosa</i>. [PDF]

Front Microbiol
Frontiers Production Office.
europepmc   +1 more source