Results 21 to 30 of about 142,289 (185)

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

Reinventing Therapeutic Proteins: Mining a Treasure of New Therapies

Biologics, 2023
Reinventing approved therapeutic proteins for a new dose, a new formulation, a new route of administration, an improved safety profile, a new indication, or a new conjugate with a drug or a radioactive source is a creative approach to benefit from the ...
Sarfaraz K. Niazi, Zamara Mariam
doaj   +1 more source

Repurposing the Veterinary Antibiotic Apramycin for Antibacterial and Antibiofilm Activity Against Pseudomonas aeruginosa From Cystic Fibrosis Patients

Frontiers in Microbiology, 2022
Objectives:To evaluate the in vitro antibacterial, antibiofilm, and antivirulence activities of apramycin, comparatively to tobramycin, against a set of P.
Giovanni Di Bonaventura, Giovanni Di Bonaventura, Veronica Lupetti, Veronica Lupetti, Fabio Verginelli, Fabio Verginelli, Sara Giancristofaro, Sara Giancristofaro, Sara Giancristofaro, Rosemary Barbieri, Rosemary Barbieri, Giovanni Gherardi, Arianna Pompilio   +12 more
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Drug Repositioning for Effective Prostate Cancer Treatment

Frontiers in Physiology, 2018
Drug repositioning has gained attention from both academia and pharmaceutical companies as an auxiliary process to conventional drug discovery. Chemotherapeutic agents have notorious adverse effects that drastically reduce the life quality of cancer ...
Beste Turanli, Beste Turanli, Beste Turanli, Morten Grøtli, Jan Boren, Jens Nielsen, Mathias Uhlen, Kazim Y. Arga, Adil Mardinoglu, Adil Mardinoglu   +9 more
doaj   +1 more source

ImmPort, toward repurposing of open access immunological assay data for translational and clinical research [PDF]

, 2018
Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging ...
Bhattacharya, Sanchita, Butte, Atul, Chen, Jieming, Dunn, Patrick, Hu, Zicheng, Schaefer, Henry, Shankar, Ravi, Shen-Orr, Shai, Smith, Barry, Thomas, Cristel, Thomson, Elizabeth, Wiser, Jeffrey, Zalocusky, Kelly   +12 more
core   +2 more sources

A brief overview of current drug repurposing approaches for COVID-19 management [PDF]

, 2020
This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares, Thomaz, Douglas Vieira   +1 more
core   +2 more sources

Repurposing

, 2023
The book chapter explores repurposing as an innovation strategy for product development in various industries. While the general mindset around innovation is about creating something new, less emphasis has been placed on managing innovation and new product development based on new applications of existing solutions.
Hanisch, Marvin, Rake, Bastian
openaire   +3 more sources

The Repurposing of Anti-Psychotic Drugs, Quetiapine and Olanzapine, as Anti-Cryptococcus Drugs

Frontiers in Microbiology, 2017
The management of cryptococcal infections is often difficult. This can, in part, be attributed to the fungistatic nature of fluconazole, which may result in cells disseminating to give rise to pathogen-emergent psychosis following brain inflammation ...
Adepemi O. Ogundeji, Carolina H. Pohl, Olihile M. Sebolai   +2 more
doaj   +1 more source

Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review

Viruses, 2020
The need for proven disease-specific treatments for the novel pandemic coronavirus SARS-CoV-2 necessitates a worldwide search for therapeutic options. Since the SARS-CoV-2 virus shares extensive homology with SARS-CoV and MERS-CoV, effective therapies ...
Jennifer Santos, Stephanie Brierley, Mohit J. Gandhi, Michael A. Cohen, Phillip C. Moschella, Arwen B. L. Declan   +5 more
doaj   +1 more source