Results 31 to 40 of about 139,836 (280)
Reuse remix recycle: repurposing archaeological digital data [PDF]
, 2018 Preservation of digital data is predicated on the expectation of its reuse, yet that expectation has never been examined within archaeology. While we have extensive digital archives equipped to share data, evidence of reuse seems paradoxically limited ...
Huggett, Jeremy
core +1 more source
Repurposing drugs to target nonalcoholic steatohepatitis [PDF]
, 2019 Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José +1 more
core +1 more source
Universa Medicina, 2023 Background Urinary tract infections are often initiated by indwelling catheters and bring about serious consequences, especially when they are caused by multidrug-resistant bacterial pathogens.
Muhammad Musthafa Poyil +2 more
doaj +1 more source
A Churn for the Better: Localizing Censorship using Network-level Path Churn and Network Tomography [PDF]
, 2017 Recent years have seen the Internet become a key vehicle for citizens around the globe to express political opinions and organize protests. This fact has not gone unnoticed, with countries around the world repurposing network management tools (e.g., URL ...
Anonymous +8 more
core +3 more sources
Repurposing Pilocarpine Hydrochloride for Treatment of
mSphere, 2019 Acetylcholine modulates the virulence of Candida albicans and regulates an appropriate immune response to infection in a Galleria mellonella infection model. Indeed, the evidence suggests that C.
Christopher Nile +11 more
doaj +1 more source
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]
, 2014 Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S. +7 more
core +4 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Malaria, a disease caused by the protozoan parasites Plasmodium spp., is still causing serious problems in endemic regions in the world. Although the WHO recommends artemisinin combination therapies for the treatment of malaria patients, the emergence of
Takuro Endo +3 more
doaj +1 more source
In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. [PDF]
, 2016 The long-term overall survival of Ewing sarcoma (EWS) patients remains poor; less than 30% of patients with metastatic or recurrent disease survive despite aggressive combinations of chemotherapy, radiation and surgery.
Alturkmani, Hani +11 more
core +3 more sources
Therapeutic status of hydroxychloroquine in COVID-19: A review
Journal of Anaesthesiology Clinical Pharmacology, 2020 Hydroxychloroquine (HCQ), a 4-aminoquinoline, is used worldwide mainly for its role in management of malaria and rheumatoid arthritis. In the present pandemic of coronavirus disease (COVID)-2019, the drug is being repurposed, based on its in vitro ...
Kirandeep Kaur +2 more
doaj +1 more source
Repurposing designed mutants: a valuable strategy for computer-aided laccase engineering – the case of POXA1b [PDF]
, 2017 The broad specificity of laccases, a direct consequence of their shallow binding site, makes this class of enzymes a suitable template to build specificity toward putative substrates.
Giacobelli, Valerio G. +6 more
core +2 more sources