Results 41 to 50 of about 142,289 (185)

The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis

Frontiers in Pharmacology, 2019
Pre-exposure prophylaxis (PrEP) is considered one of the five “pillars” by UNAIDS to reduce HIV transmission. Moreover, it is a tool for female self-protection against HIV, making it highly relevant to sub-Saharan regions, where women have the highest ...
Sulav Duwal, Daniel Seeler, Laura Dickinson, Saye Khoo, Max von Kleist   +4 more
doaj   +1 more source

Unlocking the potential of approved drugs for the allosteric inhibition of tropomyosin-receptor kinase A using molecular docking and molecular dynamics studies

Frontiers in Chemistry, 2023
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar, Nihal Abdelmoniem, Hisham A. Elrufaie, Alaa Edris, Hiba Ghaboosh, Mohanad A. Mahgoub, Elrashied A. E. Garelnabi, Wadah Osman, Wadah Osman, Asmaa E. Sherif, Asmaa E. Sherif, Ahmed Ashour, Ahmed Ashour, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Rawan Bafail, Sabrin R. M. Ibrahim, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Abdulrahim A. Alzain   +20 more
doaj   +1 more source

Advances in Repurposing and Recycling of Post-Vehicle-Application Lithium-Ion Batteries [PDF]

, 2016
Increased electrification of vehicles has increased the use of lithium-ion batteries for energy storage, and raised the issue of what to do with post-vehicle-application batteries. Three possibilities have been identified: 1) remanufacturing for intended
Baine, Nicholas, Corneal, Lindsay, Standridge, Charles R.   +2 more
core   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]

, 2020
BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine, Hewit, Kay, James, Daniel, Leung, Hing, Munnings-Tomes, Sophie, Patel, Rachana, Rushworth, Linda, Shanks, Emma, Somani, Sukrut, Straube, Anne   +9 more
core   +3 more sources

Phenotype versus genotype to optimize cancer dosing in the clinical setting—focus on 5‐fluorouracil and tyrosine kinase inhibitors

Pharmacology Research & Perspectives
Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival.
Jennifer H. Martin, Peter Galettis, Alex Flynn, Jennifer Schneider   +3 more
doaj   +1 more source

Montelukast: The New Therapeutic Option for the Treatment of Epilepsy

Journal of Experimental Pharmacology, 2021
Bekalu Amare Tesfaye, Haftom Gebregergs Hailu, Kaleab Alemayehu Zewdie, Muluken Altaye Ayza, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Haftom Gebregergs Hailu ...
Tesfaye BA, Hailu HG, Zewdie KA, Ayza MA, Berhe DF   +4 more
doaj  

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

Molecules, 2019
Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists
Ana Teresa Silva, Clara M. Bento, Ana C. Pena, Luísa M. Figueiredo, Cristina Prudêncio, Luísa Aguiar, Tânia Silva, Ricardo Ferraz, Maria Salomé Gomes, Cátia Teixeira, Paula Gomes   +10 more
doaj   +1 more source

Repurposing Antipsychotics for Cancer Treatment

Biomedicines, 2021
Cancer is a leading cause of death worldwide, with approximately 19 million new cases each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently inhibiting tumor growth and proliferation. However, developing a new drug is a
Nikolaos Vlachos, Marios Lampros, Spyridon Voulgaris, George A. Alexiou   +3 more
doaj   +1 more source

The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity

Microbiology Spectrum
Tuberculosis remains the deadliest infectious disease of the 21st century. New antimicrobials are needed to improve treatment outcomes and enable therapy shortening. Drug repurposing is an alternative to the traditional drug discovery process.
José Manuel Ezquerra-Aznárez, Henrich Gašparovič, Álvaro Chiner-Oms, Ainhoa Lucía, Jesús Blázquez, Iñaki Comas, Jana Korduláková, José A. Aínsa, Santiago Ramón-García   +8 more
doaj   +1 more source