Results 41 to 50 of about 139,836 (280)
Nucleotide analogues and mpox: Repurposing the repurposable
Antiviral ResearchWhile the COVID-19 crisis is still ongoing, a new public health threat has emerged with recent outbreaks of monkeypox (mpox) infections in Africa. Mass vaccination is not currently recommended by the World Health Organization (WHO), and antiviral treatments are yet to be specifically approved for mpox, although existing FDA-approved drugs (Tecovirimat,
Ashleigh Shannon, Bruno Canard
openaire +5 more sources
The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis
Frontiers in Pharmacology, 2019 Pre-exposure prophylaxis (PrEP) is considered one of the five “pillars” by UNAIDS to reduce HIV transmission. Moreover, it is a tool for female self-protection against HIV, making it highly relevant to sub-Saharan regions, where women have the highest ...
Sulav Duwal +4 more
doaj +1 more source
Frontiers in Chemistry, 2023 Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases.
Rua M. Mukhtar +20 more
doaj +1 more source
Advances in Repurposing and Recycling of Post-Vehicle-Application Lithium-Ion Batteries [PDF]
, 2016 Increased electrification of vehicles has increased the use of lithium-ion batteries for energy storage, and raised the issue of what to do with post-vehicle-application batteries. Three possibilities have been identified: 1) remanufacturing for intended
Baine, Nicholas +2 more
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Pharmacology Research & PerspectivesCancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival.
Jennifer H. Martin +3 more
doaj +1 more source
Montelukast: The New Therapeutic Option for the Treatment of Epilepsy
Journal of Experimental Pharmacology, 2021 Bekalu Amare Tesfaye, Haftom Gebregergs Hailu, Kaleab Alemayehu Zewdie, Muluken Altaye Ayza, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Haftom Gebregergs Hailu ...
Tesfaye BA +4 more
doaj
Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs
Molecules, 2019 Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists
Ana Teresa Silva +10 more
doaj +1 more source
Understanding tissue morphology: model repurposing using the CoSMoS process [PDF]
, 2014 We present CoSMoS as a way of structuring thinking on how to reuse parts of an existing model and simulation in a new model and its implementation. CoSMoS provides a lens through which to consider, post-implementation, the assumptions made during the ...
Bown, James L. +4 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source