Results 151 to 160 of about 4,264,708 (345)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Leveraging generative AI to enhance Synthea model development. [PDF]

JAMIA Open
Kramer MA, Mathur A, Adams CE, Walonoski JA.   +3 more
europepmc   +1 more source

CONTROL PROGRAM DEVELOPMENT BY RANKING METHOD OF REQUIREMENTS TO DESIGN-TECHNOLOGICAL ELEMENTS BASED ON DIFFERENT CAD

, 2017
Евгений Дьяченко, E.A. DYACHENKO, Анатолий Рыбаков, Anatoly Rybakov, Александр Шурпо, Александр Шурпо   +5 more
openalex   +2 more sources

In Defense of a Social Value Requirement for Clinical Research

Bioethics, 2017
D. Wendler, A. Rid
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Prior Authorization Requirements and Prescription Fill Patterns Among Patients With Heart Failure. [PDF]

JACC Adv
Mukhopadhyay A, Adhikari S, Li X, Kazi DS, Berman AN, Kronish I, Hamo C, Dodson JA, Chunara R, Ladino N, Reynolds HR, Katz SD, Blecker S.   +12 more
europepmc   +1 more source

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin [PDF]

, 2013
Po‐Chang Chiang, Harvey Wong
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Detection of Antigen-Specific B Cells in Patients with Pemphigus Vulgaris by Enzyme-Linked Immunospot Assay: Requirement of T Cell Collaboration for Autoantibody Production [PDF]

, 2000
Koji Nishifuji, Masayuki Amagai, Masataka Kuwana, Toshiro Iwasaki, Takeji Nishikawa   +4 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source