Results 161 to 170 of about 1,527,874 (317)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Systemic Inflammation Response Index Predicts Thrombolytic Therapy Requirement in Intermediate-High Risk Acute Pulmonary Embolism: A Retrospective Study. [PDF]

J Clin Med
Çiçek T, Yeşildağ K.
europepmc   +1 more source

Alcohol Treatment Requirement (ATR): Peer-reviewed research on the effectiveness and impact of sentences, orders, and requirements

This bulletin summarises research on the effectiveness of the alcohol treatment requirement (ATR) for Community Orders and Suspended Sentence Orders in England and Wales for convicted adults. Effectiveness is considered in terms of fulfilling the aims of
Gormley, Jay, Hamilton, Melissa
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

No Significant Difference Is Not Equivalence: Statistical Considerations on Phenylephrine Requirement in Left-Tilt versus Supine Cesarean Delivery [Response to Letter]. [PDF]

Drug Des Devel Ther
Yu XQ, Xiao F.
europepmc   +1 more source

Awareness Requirements [PDF]

, 2013
Vítor Estêvão Silva Souza, Alexei Lapouchnian, William N. Robinson, John Mylopoulos   +3 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Glycemic Control and Insulin Requirement According to Enteral Formula Type in Critically Ill Patients with Type 2 Diabetes: A Retrospective Comparative Study. [PDF]

Nutrients
Ekin S, Gülen D, Ceylan İ, Özyaprak B, Kılınç K, Öztürk A.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prognostic Factors and Clinical Outcomes in Critically Ill Patients with Hematological Malignancies in the Intensive Care Unit. [PDF]

J Clin Med
Yüksel RC, Kaynar AS, Metin H, Temel Ş, Baran Ünal C, Yılmaz Z, Akyol G, Gündoğan K, Sungur M.   +8 more
europepmc   +1 more source