Results 201 to 210 of about 7,835,270 (328)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice.

Journal of Infectious Diseases, 2004
Weitao Huang, L. Na, P. Fidel, P. Schwarzenberger   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Designing a Requirement Mining System

Journal of the AIS, 2015
Hendrik Meth, B. Müller, A. Maedche
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages.

Blood, 2009
Mihea G Netea, Mihea G Netea, C. Nold-Petry, M. Nold, L. Joosten, B. Opitz, J. V. D. Meer, F. Veerdonk, G. Ferwerda, B. Heinhuis, I. Devesa, C. Funk, R. Mason, B. Kullberg, A. Rubartelli, J. W. M. V. D. Meer, C. Dinarello   +16 more
semanticscholar   +1 more source

Using Generative Artificial Intelligence (AI) to Compare Commission on Osteopathic College Accreditation (COCA) and Liaison Committee on Medical Education (LCME) Standards. [PDF]

Cureus
Hedrick JS, Cottrell SA, Nield LS, Ferrari N.   +3 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.

Proceedings of the National Academy of Sciences of the United States of America, 1997
G. B. Udy, Raewyn P. Towers, R. Snell, R. Wilkins, Soo-Hee Park, P. Ram, D. Waxman, H. W. Davey   +7 more
semanticscholar   +1 more source

Procedural separation of appetitive and consummatory behaviors in operant ethanol self-administration: A review and open-source analytical framework. [PDF]

Alcohol Clin Exp Res (Hoboken)
Colarusso OA, Weiner JL.
europepmc   +1 more source