Results 101 to 110 of about 1,519,620 (289)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A 10,000-hr life test of an engineering model resistojet [PDF]

One of the major issues associated with using resistojet thrusters on Space Station Freedom is the long life required. An engineering model resistojet was life-tested to determine if it was capable of meeting that requirement.
Slutz, Rodger J.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

User-oriented requirements engineering [PDF]

2014 IEEE 2nd International Workshop on Usability and Accessibility Focused Requirements Engineering (UsARE), 2014
A method for analysing emotion and motivation in requirements engineering (RE) is described. The method extends personal RE where requirements are for individual users and their needs. Theories from the psychology of emotion and motivation are introduced and applied in a top-down pathway motivated by system goals to influence users, and a bottom-up ...
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Model-Based Systems Engineering for Digital Twin System Development Applied to an Aircraft Seat Test Bench

IEEE Access
In recent years, the Digital Twin has attracted significant attention in academia and industry as a powerful technology for creating virtual replicas of physical systems tailored to specific purposes.
Agnese Pasquariello, Imane Bouhali, Dominik Leherbauer, Nourhene Abdeljabbar, Faida Mhenni, Stanislao Patalano, Peter Hehenberger, Andrea Rega   +7 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Formal Modeling and Analysis Method for Hierarchical Requirements of Airborne Software

Nanjing Hangkong Hangtian Daxue Xuebao
The increasingly complex multi-level functional requirements bring challenges to the design and development of safety-critical airborne software. A formal modeling and analysis method of software requirements with hierarchical semantic characteristics ...
WANG Kangxing, HU Jun, WANG Lisong, DING Ding, DONG Yajiong, DAI Jialei   +5 more
doaj   +1 more source

DIDET: Digital libraries for distributed, innovative design education and teamwork. Final project report [PDF]

, 2008
The central goal of the DIDET Project was to enhance student learning opportunities by enabling them to partake in global, team based design engineering projects, in which they directly experience different cultural contexts and access a variety of ...
Breslin, C., Grierson, H., JISC (Joint Information Systems Committee)   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source