Results 81 to 90 of about 217,174 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Formal Modeling and Analysis Method for Hierarchical Requirements of Airborne Software

Nanjing Hangkong Hangtian Daxue Xuebao
The increasingly complex multi-level functional requirements bring challenges to the design and development of safety-critical airborne software. A formal modeling and analysis method of software requirements with hierarchical semantic characteristics ...
WANG Kangxing, HU Jun, WANG Lisong, DING Ding, DONG Yajiong, DAI Jialei   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Resilience-by-Design: Extracting Resilience Requirements Using the Resilience Graph in the Automotive Concept Phase

Future Internet
The complexity and interconnectivity of modern automotive systems are rapidly increasing, particularly with the rise of distributed and cooperative driving functions. These developments increase exposure to a range of disruptions, from technical failures
Isaac Mpidi Bita, Elif Ugur, Aschot Hovemann, Roman Dumitrescu   +3 more
doaj   +1 more source

Attributes of a great requirements engineer

Journal of Systems and Software
[Context and Motivation] Several studies have investigated attributes of great software practitioners. However, the investigation of such attributes is still missing in Requirements Engineering (RE). The current knowledge on attributes of great software practitioners might not be easily translated to the context of RE because its activities are ...
Larissa Barbosa L. Pinheiro, Sávio Freire, Rita Suzana Pitangueira Maciel, Manoel G. Mendonça, Marcos Kalinowski, Zadia Codabux, Rodrigo O. Spínola   +6 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Runtime and Design Time Completeness Checking of Dangerous Android App Permissions Against GDPR

IEEE Access
Data and privacy laws, such as the GDPR, require mobile apps that collect and process the personal data of their citizens to have a legally-compliant policy.
Ryan Mcconkey, Oluwafemi Olukoya
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

A Social-Network-Based Crowd Selection Approach for Crowdsourcing Mobile Apps Requirements Engineering Tasks

Applied Sciences
Mobile apps have revolutionized almost every aspect of our daily lives, shaping the way we shop, learn and work. The transformative and unprecedented impact they have made on our lifestyle and the convenience they have offered have increased their ...
Ghadah Alamer, Sultan Alyahya, Hmood Al-Dossari   +2 more
doaj   +1 more source