Results 71 to 80 of about 1,519,620 (289)
Requirement engineering of a Cooperative Information System using viewpoints [PDF]
, 2014 International audienceIn this paper we are interested in cooperative infor-mation systems (CIS) in inter-organizational environments. They are information systems on a large scale, which con-nect different organizations, often autonomous, sharing common ...
Alimazighi, Zaia +2 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Deriving Information Requirements from Responsibility Models [PDF]
, 2009 This paper describes research in understanding the requirements for complex information systems that are constructed from one or more generic COTS systems.
Dobson, J. +3 more
core +4 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Designing Requirements Engineering Research [PDF]
2007 Fifth International Workshop on Comparative Evaluation in Requirements Engineering, 2007 Engineering sciences study different topics than natural sciences, and utility is an essential factor in choosing engineering research problems. But despite these differences, research methods for the engineering sciences are no different than research methods for any other kind of science. At most there is a difference in emphasis.
Wieringa, Roelf J. +1 more
openaire +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Towards a methodology for rigorous development of generic requirements patterns
, 2005 We present work in progress on a methodology for the engineering, validation and verification of generic requirements using domain engineering and formal methods.
Johnson, Ian +2 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
On Composing Separated Concerns, Composability and Composition Anomalies [PDF]
, 2000 It is generally acknowledged that separation of concerns is a key requirement for effective software engineering: it helps in managing the complexity of software and supports the maintainability of a software system.
Aksit, Mehmet +3 more
core +2 more sources