Results 101 to 110 of about 7,965,717 (326)

Space-based geoengineering: challenges and requirements [PDF]

, 2009
The prospect of engineering the Earth's climate (geoengineering) raises a multitude of issues associated with climatology, engineering on macroscopic scales, and indeed the ethics of such ventures.
Early J. T., Gehrels T., Hudson H., Mautner M., McGuffie K., McInnes C. R., Struck C., Teller E.   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

From types to type requirements: Genericity for model-driven engineering [PDF]

, 2013
The final publication is available at Springer via http://dx.doi.org/10.1007/s10270-011-0221-0Model-driven engineering (MDE) is a software engineering paradigm that proposes an active use of models during the development process.
Guerra, Esther, Lara, Juan de
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Environmental sustainability requirement specification levels for comprehensive requirements engineering

Cleaner Environmental Systems
The consideration of sustainability early in product development presents significant challenges for the field of mechanical engineering. Linking broad corporate strategies to specific product attributes such as dimensions and functions requires repeated,
Niklas Quernheim, Benjamin Schleich
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Natural Language Processing for Requirements Engineering: The Best Is Yet to Come

IEEE Software, 2018
As part of the growing interest in natural language processing for requirements engineering (RE), RE researchers, computational linguists, and industry practitioners met at the First Workshop on Natural Language Processing for Requirements Engineering ...
F. Dalpiaz, Alessio Ferrari, Xavier Franch, Cristina Palomares   +3 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Engineering Safety- and Security-Related Quality Requirements

Technical Transactions, 2019
Safety- and security-related problems for software intensive systems are often due to poor or missing relevant engineering requirements. Although there is nothing really new in our presentation, specified problems and methods are well worth revisiting ...
Stojek Małgorzata
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source