Results 91 to 100 of about 150,906 (264)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2014 Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Eres, M.H. +8 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2008 Complex decision-making is a prominent aspect of requirements engineering (RE) and the need for improved decision support for RE decision-makers has been identified by a number of authors in the research literature.
Persson, Anne,, Alenljung, Beatrice,
core +1 more source
, 2022 S.267-272Early orientation towards tasks of the application domain to be supported by a software system has been proposed as a fruitful means for achieving more appropriate and usable systems as well as for focusing the requirements engineering process ...
Doerr, Joerg +3 more
core +1 more source
Characterizing Efficacy of Alternative Media for Requirements Expression
SystemsRequirements are most commonly expressed in natural language, but alternative media can be employed. Previous research has established the viability of model diagrams and engineering drawings for requirements expression.
Jason Kolligs, Lawrence Dale Thomas
doaj +1 more source
Security and Trust Requirements Engineering [PDF]
, 2005 Integrating security concerns throughout the whole software development process is one of today’s challenges in software and requirements engineering research. A challenge that so far has proved difficult to meet. The major difficulty is that providing security does not only require to solve technical problems but also to reason on the organization as ...
Giorgini, Paolo +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Tools for Requirements Engineering
IEEE SoftwareRequirements engineering needs a good process and the right tool. Yet in many companies I observe unsuitable use of tools. Missing, wrong, and changing requirements are major failure points. Tools for requirements facilitate professional and efficient engineering throughout the lifecycle.
Juan Manuel Carrillo de Gea +5 more
openaire +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source