Results 71 to 80 of about 6,871,110 (300)

Engineering Safety- and Security-Related Quality Requirements

Technical Transactions, 2019
Safety- and security-related problems for software intensive systems are often due to poor or missing relevant engineering requirements. Although there is nothing really new in our presentation, specified problems and methods are well worth revisiting ...
Stojek Małgorzata
doaj   +1 more source

User-oriented requirements engineering [PDF]

2014 IEEE 2nd International Workshop on Usability and Accessibility Focused Requirements Engineering (UsARE), 2014
A method for analysing emotion and motivation in requirements engineering (RE) is described. The method extends personal RE where requirements are for individual users and their needs. Theories from the psychology of emotion and motivation are introduced and applied in a top-down pathway motivated by system goals to influence users, and a bottom-up ...
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Siamese Neural Networks Method for Semantic Requirements Similarity Detection

IEEE Access
Detecting semantic similarity between textual requirements is a crucial task for various natural language processing (NLP)-based requirements engineering (RE) applications. It is also challenging due to the nature of these requirements, which are written
Nojoom A. Alnajem, Manal Binkhonain, M. Shamim Hossain   +2 more
doaj   +1 more source

Seamless Development Applicability: an Experiment

Труды Института системного программирования РАН, 2018
Requirements and code, in conventional software engineering wisdom, belong to entirely different worlds. Is it possible to unify these two worlds? A unified framework could help make software easier to change and reuse. To explore the feasibility of such
Alexandr Naumchev
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Recommendation systems-based software requirements elicitation process—a systematic literature review

Journal of Engineering and Applied Science
Requirements elicitation is one of the fundamental sub-processes of requirements engineering which is used to find the needs of stakeholders. There are several activities in this sub-process, i.e., identification of stakeholders and their requirements ...
Faiz Akram, Tanvir Ahmad, Mohd. Sadiq
doaj   +1 more source

Uncovering the Implicit: A Comparative Evaluation of Modeling Approaches for Environmental Assumptions

Applied Sciences
This paper presents an extended investigation into the role of environmental assumptions in the emergence and management of Requirements Technical Debt (RTD).
Mounifah Alenazi
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source