Results 51 to 60 of about 363,478 (268)
Cleaner Environmental SystemsThe consideration of sustainability early in product development presents significant challenges for the field of mechanical engineering. Linking broad corporate strategies to specific product attributes such as dimensions and functions requires repeated,
Niklas Quernheim, Benjamin Schleich
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Engineering Safety- and Security-Related Quality Requirements
Technical Transactions, 2019 Safety- and security-related problems for software intensive systems are often due to poor or missing relevant engineering requirements. Although there is nothing really new in our presentation, specified problems and methods are well worth revisiting ...
Stojek Małgorzata
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User-oriented requirements engineering [PDF]
2014 IEEE 2nd International Workshop on Usability and Accessibility Focused Requirements Engineering (UsARE), 2014 A method for analysing emotion and motivation in requirements engineering (RE) is described. The method extends personal RE where requirements are for individual users and their needs. Theories from the psychology of emotion and motivation are introduced and applied in a top-down pathway motivated by system goals to influence users, and a bottom-up ...
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Study of Emotions in Requirements Engineering [PDF]
, 2010 Requirements engineering (RE) is a crucial activity in software development projects. This phase in the software development cycle is knowledge intensive, and thus, human capital intensive. From the human point of view, emotions play an important role in behavior and can even act as behavioral motivators.
Ricardo Colomo-Palacios +3 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Journal of Engineering and Applied ScienceRequirements elicitation is one of the fundamental sub-processes of requirements engineering which is used to find the needs of stakeholders. There are several activities in this sub-process, i.e., identification of stakeholders and their requirements ...
Faiz Akram, Tanvir Ahmad, Mohd. Sadiq
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Siamese Neural Networks Method for Semantic Requirements Similarity Detection
IEEE AccessDetecting semantic similarity between textual requirements is a crucial task for various natural language processing (NLP)-based requirements engineering (RE) applications. It is also challenging due to the nature of these requirements, which are written
Nojoom A. Alnajem +2 more
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