Results 61 to 70 of about 6,871,110 (300)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Requirements engineering for business workflow systems: a scenario-based approach [PDF]
, 2001 Workflow implementations require a deep understanding of business and human cooperation. Several approaches have been proposed to address this need for understanding, but largely in a descriptive way. Attempts to use them in software development have had
Strassl, Johann Gerhard, Strassl, J.G.
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cleaner Environmental SystemsThe consideration of sustainability early in product development presents significant challenges for the field of mechanical engineering. Linking broad corporate strategies to specific product attributes such as dimensions and functions requires repeated,
Niklas Quernheim, Benjamin Schleich
doaj +1 more source
A Study of Emotions in Requirements Engineering [PDF]
, 2010 Requirements engineering (RE) is a crucial activity in software development projects. This phase in the software development cycle is knowledge intensive, and thus, human capital intensive. From the human point of view, emotions play an important role in behavior and can even act as behavioral motivators.
Ricardo Colomo-Palacios +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Requirements engineering: a close look at industry needs and a model curricula [PDF]
, 2004 Research endeavours in software development have found that failures and deficiencies of software systems are often rooted in the requirements activities undertaken.
Oliver Minor +5 more
core +1 more source
Specifying a framework for evaluating requirements engineering technology
, 2022 S.1-8Evaluating requirements engineering technology is a challenging activity. It becomes even more difficult when having to evaluate the technology and thus to show its suitability in real settings, as access to industrial resources might be limited and
Verhulst, E. +2 more
core +1 more source