Results 51 to 60 of about 344,051 (254)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Engineering Safety- and Security-Related Quality Requirements
Technical Transactions, 2019 Safety- and security-related problems for software intensive systems are often due to poor or missing relevant engineering requirements. Although there is nothing really new in our presentation, specified problems and methods are well worth revisiting ...
Stojek Małgorzata
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Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Engineering and Applied ScienceRequirements elicitation is one of the fundamental sub-processes of requirements engineering which is used to find the needs of stakeholders. There are several activities in this sub-process, i.e., identification of stakeholders and their requirements ...
Faiz Akram, Tanvir Ahmad, Mohd. Sadiq
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Seamless Development Applicability: an Experiment
Труды Института системного программирования РАН, 2018 Requirements and code, in conventional software engineering wisdom, belong to entirely different worlds. Is it possible to unify these two worlds? A unified framework could help make software easier to change and reuse. To explore the feasibility of such
Alexandr Naumchev
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Siamese Neural Networks Method for Semantic Requirements Similarity Detection
IEEE AccessDetecting semantic similarity between textual requirements is a crucial task for various natural language processing (NLP)-based requirements engineering (RE) applications. It is also challenging due to the nature of these requirements, which are written
Nojoom A. Alnajem +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Provenance-Based Trust-Aware Requirements Engineering Framework for Self-Adaptive Systems. [PDF]
Sensors (Basel), 2023 Lee HC, Lee SW.
europepmc +1 more source