Results 71 to 80 of about 4,368,218 (320)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Rationale Management Challenges in Requirements Engineering [PDF]

, 2010
Rationale and rationale management have been playing an increasingly prominent role in software system development mainly due to the knowledge demand during system evaluation, maintenance, and evolution, especially for large and complex systems.
Avgeriou, Paris,, He, Keqing,, Liang, Peng,   +2 more
core   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Модель та інформаційна технологія побудови адаптивної матриці трасування вимог у гнучких процесах розробки програмного забезпечення [PDF]

, 2013
Some features of requirements management in agile software development are considered, and problem actuality to elaborate respective requirements traceability tools for their effective implementation is defined. An approach is proposed, which is based on
Тамзаєв, Р. О., Ткачук, Микола Вячеславович   +1 more
core  

An Approach to Generate the Traceability Between Restricted Natural Language Requirements and AADL Models

IEEE Transactions on Reliability, 2020
Requirements traceability is broadly recognized as a critical element of any rigorous software development process, especially for building safety-critical software (SCS) systems. Model-driven development (MDD) is increasingly used to develop SCS in many
Fei Wang, Zhibin Yang, Zhiqiu Huang, Chengwei Liu, Yong Zhou, J. Bodeveix, M. Filali   +6 more
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

META-MODELING CONSTRUCTS FOR REQUIREMENTS REUSE (RR): SOFTWARE REQUIREMENTS PATTERNS, VARIABILITY AND TRACEABILITY

Malaysian Journal of Computing, 2018
Reuse is a fundamental activity, which increases quality and productivity of software products. Reuse of software artifacts, such as requirements, architectures, and codes can be employed at any developmental stage of software. However, reuse at a higher
Badamasi Imam Ya’u, Azlin Nordin, Norsaremah Salleh
doaj   +1 more source

Tool Support for Validation of Formal System Models: Interactive Visualization and Requirements Traceability [PDF]

Electronic Proceedings in Theoretical Computer Science, 2019
Development processes in various engineering disciplines are incorporating formal models to ensure safety properties of critical systems. The use of these formal models requires to reason about their adequacy, i.e., to validate that a model mirrors the ...
Eduard Kamburjan, Jonas Stromberg
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Blockchain-Based Information Security Protection Mechanism for the Traceability of Intellectual Property Transactions

Sensors
Traditional intellectual property transaction traceability has problems such as information asymmetry, traceability information storage methods relying on centralized databases, and easy tampering of transaction information, etc.
Zheng Wang, Wenlong Feng, Mengxing Huang, Siling Feng, Shilong Mo, Yunhong Li   +5 more
doaj   +1 more source