Results 91 to 100 of about 23,387 (216)

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Real-time in situ viability assessment in a 3D bioreactor with liver cells using resazurin assay.

, 2013
peer reviewedThree-dimensional cultivation of human cells is promising especially for long-term maintenance of specific functions and mimicking the in vivo tissue environment.
Mueller, Daniel, Tascher, Georg, NOOR, Fozia, Heinzle, Elmar, Damm, Georg, Nussler, Andreas K.   +5 more
core   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics.
M. Shamim Hasan Zahid, Monica M. Johnson, Robert J. Tokarski, II, Abhay R. Satoskar, James R. Fuchs, Eric M. Bachelder, Kristy M. Ainslie   +6 more
doaj   +1 more source

Co‐Culture of Mammalian Cells and Photosynthetic Microorganisms for Oxygen Supply in Engineered Tissues

Cell Proliferation, EarlyView.
Continuous 28‐day light exposure alters behaviours of articular cartilage progenitor cells (ACPCs) and mesenchymal stromal cells (MSCs). Co‐culture with Leptolyngbya and Synechococcus does not adversely affect the chondrogenic capacity of ACPCs over a 28‐day period, in contrast to co‐culture with Chlorella.
Meng Wang, Ahmad Furqan Hala, Vera van der Niet, Sebastian T. Bok, Aylin Kara Özenler, Marcel Janssen, Maria J. Barbosa, Dirk Martens, Rene H. Wijffels, Jos Malda, Mylène de Ruijter   +10 more
wiley   +1 more source

Accelerated electrochemical antibiotic susceptibility testing using disposable electrodes and Resazurin

Stenotrophomonas maltophilia and Shigella sonnei are increasingly associated with serious infections and shigellosis, respectively, with conventional antibiotic susceptibility tests requiring 18–24 h or more, often delaying treatment.
Topkaya, Seda Nur, Tekintas, Yamaç, Isbilir, Hasan, Kaya, Hüseyin Oğuzhan, Temel, Aybala, Karadeniz, Hakan, TOPKAYA ÇETİN, SEDA NUR   +6 more
core   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Adsorption of resazurin by poly(acrylic acid) hydrogels and evaluation of its use in reduction assay for quantification of cell viability

, 2020
WOS:000603542900006Resazurin is a nonfluorescent blue dye which is reduced to a fluorescent pink resorufin via enzymatic activity of living cells. Therefore, a resazurin reduction-based assay serves as an effective method for evaluating cell viability ...
Bayraç, Ceren, Şener, Berke Bilgenur, Varçin, Merve   +2 more
core   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

An Investigation of the Interaction between Resazurin and Cd2+ and Zn2+ Ions in Aqueous Medium

, 2010
The voltammetric behaviour of resazurin in the presence of Cd2+ and Zn2+ ions at a hanging mercury drop electrode (HMDE) was investigated by using square wave voltammetry (SWV), cyclic voltammetry (CV) and adsorptive square wave voltammetry (AdsSWV). The
ARSLAN KARAHAN, EMİNE, Cakir, Semiha
core