Results 81 to 90 of about 24,024 (231)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Antimycobacterial screening of selected medicinal plants against Mycobacterium tuberculosis H37Rv using agar dilution method and the microplate resazurin assay

International Journal of Mycobacteriology, 2020
Background: Tuberculosis (TB), has been serious disease to the global human population causing millions of deaths worldwide. The recent increase in the number of multi-drug resistant clinical isolates of Mycobacterium tuberculosis has created an urgent ...
K. Jethva, Dhara Bhatt, M. Zaveri
semanticscholar   +1 more source

Faecal Microbiota Transplantation in Anorexia Nervosa: A Systematic Review of Methodologies, Outcomes, and Challenges With Recommendations for Future Studies

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder displaying an altered gut microbiome. Faecal microbiome transplantation (FMT) has emerged as a powerful research tool and potential treatment option in AN due to the microbiome‐gut‐brain axis. Current studies are limited and reveal variable FMT protocols.
Anna C. Thelen, Nele M. Korten, Larissa Blischke, Clara Voelz, Cordian Beyer, Jochen Seitz, Stefanie Trinh   +6 more
wiley   +1 more source

TcSR62, an RNA-binding protein, as a new potential target for anti-trypanocidal agents

Frontiers in Microbiology
Trypanosomatids are parasites of health importance that cause neglected diseases in humans and animals. Chagas’ disease, caused by Trypanosoma cruzi, affects 6–7 millions of people worldwide, mostly in Latin America, most of whom do not have access to ...
Analía G. Níttolo, Analía G. Níttolo, Agustina M. Chidichimo, Agustina M. Chidichimo, Ana L. Benacerraf, Timothy Cardozo, M. Clara Corso, M. Clara Corso, Valeria Tekiel, Valeria Tekiel, Javier G. De Gaudenzi, Javier G. De Gaudenzi, Gabriela Vanesa Levy, Gabriela Vanesa Levy   +13 more
doaj   +1 more source

A simple method to measure cell viability in proliferation and cytotoxicity assays

Brazilian Oral Research, 2009
Resazurin dye has been broadly used as indicator of cell viability in several types of assays for evaluation of the biocompatibility of medical and dental materials.
Ricardo Carneiro Borra, Mônica Andrade Lotufo, Sonia Maria Gagioti, Fabiana de Mesquita Barros, Priscila Maria Andrade   +4 more
doaj   +1 more source

Preclinical activity of resazurin in acute myeloid leukaemia

British Journal of Haematology
SummaryResazurin, a phenoxazine used in cell viability assays, acts in vitro as an anti‐leukaemic compound through the production of cellular reactive oxygen species (ROS) resulting in mitochondrial dysfunction and cell death. However, the in vivo tolerance and efficacy of resazurin in cancer are unknown. In this study, we investigated the in vitro and
Trung Quang Ha, Vibeke Andresen, Bjarte Skoe Erikstein, Mihaela Popa, Stein‐Erik Gullaksen, Håkon Reikvam, Emmet McCormack, Bjørn Tore Gjertsen   +7 more
openaire   +4 more sources

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

FLUOROMETRIC ASSAY FOR CELL PROLIFERATION IN HUMAN TUMOR CELL LINES APPLICATION

Vitae, 2010
Assessment of in vitro cytotoxicity as a model to explore biological activity of compounds isolated from different sources is the first approached to search molecules with potential anticancer activity.
Linamaría Escobar M., Fabio A. Aristizábal G.   +1 more
doaj  

Defining conditions for biofilm inhibition and eradication assays for Gram-positive clinical reference strains

BMC Microbiology, 2018
Background Biofilms are formed by a complex bacterial community encapsulated by a polymeric matrix, with strong adherent properties and persistent phenotype. Biofilms are considered one of the most challenging areas of modern medicine.
Cristina D. Cruz, Shreya Shah, Päivi Tammela   +2 more
doaj   +1 more source

Simplified Resazurin Rennet Test for Diagnosis of Mastitis

Journal of Dairy Science, 1978
A simplified resazurin rennet test for diagnosis of bovine mastitis was devised. A tablet of resazurin and rennet was placed in a sterile test tube to which 10 ml of milk were added directly from a teat. The test tube was incubated for 1 h at 37 C. After incubation the change in color of resazurin and the time required for coagulation by the rennet ...
openaire   +2 more sources