Results 81 to 90 of about 876,186 (303)

Plasma membrane-specific interactome analysis reveals calpain 1 as a druggable modulator of rescued Phe508del-CFTR cell surface stability [PDF]

, 2019
Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells.
Amaral, Margarida D., Barros, Patrícia, Matos, Ana Margarida, Matos, Paulo, Pepperkok, Rainer, Pinto, Francisco R.   +5 more
core  

Multiple Professional Institutes’ Scene and Corporate Rescue Work-Related Professionalism

SAGE Open
The study explored corporate rescue professionalism in a setting with multiple professional institutes. The study employed qualitative inquiry processes to gather and explore field data.
Onesmus Ayaya
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Chemical Attacks [PDF]

Bulletin of Emergency and Trauma, 2017
Objective: To evaluate the knowledge, attitude, and preparedness of Mahabad Red Crescent Society volunteers in dealing with chemical attacks.Methods: This prospective cross-sectional study was conducted on 120 Red Crescent Society volunteers in Mahabad ...
Maryam Nadjafi, Siavash Hamzeh pour
doaj   +2 more sources

"It's my calling", Canadian dog rescuers' motives and experiences for engaging in international dog rescue efforts.

PLoS ONE
The importation of rescue dogs has become an increasingly common occurrence in recent years, often involving industrialized countries as the ultimate destination. However, international dog rescue activities have attracted considerable criticism from the
Kai Alain von Rentzell, Christiana Bratiotis, Alexandra Protopopova   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Beyond neighborhood revitalization [PDF]

After community groups rescue a troubled neighborhood, the area may attract many newcomers—and become expensive. One community shows how to help activists retain the diversity of the towns they work so hard to revitalize.Community development ...
Chris Ney, Sally Swenson
core  

Memory frictions and reconciliation: Neo-victorian gothic and gender violence in Katy Darby’s The Whores’ Asylum (2012) [PDF]

, 2015
Katy Derby’s first novel, The Whores’ Asylum (2012), is an attempt to deal with the issue of prostitution and rescue work in Oxford in the 1880s. Jericho is an area where, away from the prestigious university colleges, drunkards, thieves and prostitutes ...
Romero-Ruiz, Maria Isabel
core