Results 81 to 90 of about 881,422 (304)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Multiple Professional Institutes’ Scene and Corporate Rescue Work-Related Professionalism
SAGE OpenThe study explored corporate rescue professionalism in a setting with multiple professional institutes. The study employed qualitative inquiry processes to gather and explore field data.
Onesmus Ayaya
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Beyond neighborhood revitalization [PDF]
After community groups rescue a troubled neighborhood, the area may attract many newcomers—and become expensive. One community shows how to help activists retain the diversity of the towns they work so hard to revitalize.Community development ...
Chris Ney, Sally Swenson
core
Plasma membrane-specific interactome analysis reveals calpain 1 as a druggable modulator of rescued Phe508del-CFTR cell surface stability [PDF]
, 2019 Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a chloride channel normally expressed at the surface of epithelial cells.
Amaral, Margarida D. +5 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Knowledge and Attitude of Iranian Red Crescent Society Volunteers in Dealing with Chemical Attacks [PDF]
Bulletin of Emergency and Trauma, 2017 Objective: To evaluate the knowledge, attitude, and preparedness of Mahabad Red Crescent Society volunteers in dealing with chemical attacks.Methods: This prospective cross-sectional study was conducted on 120 Red Crescent Society volunteers in Mahabad ...
Maryam Nadjafi, Siavash Hamzeh pour
doaj +2 more sources
PLoS ONEThe importation of rescue dogs has become an increasingly common occurrence in recent years, often involving industrialized countries as the ultimate destination. However, international dog rescue activities have attracted considerable criticism from the
Kai Alain von Rentzell +2 more
doaj +1 more source
SAFER: Search and Find Emergency Rover [PDF]
, 2016 When disaster strikes and causes a structure to collapse, it poses a unique challenge to search and rescue teams as they assess the situation and search for survivors.
Agustin, Zachary +5 more
core +1 more source