Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
A practical guide to the implementation of AI in orthopaedic research part 8: Resource management checklist for AI-driven research projects in orthopaedics. [PDF]
Longo UG +11 more
europepmc +1 more source
Publication rates and characteristics of PGY2 psychiatric pharmacy resident research projects. [PDF]
Antley DL +7 more
europepmc +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A guided ungrading example for independent research projects in an upper-division ecosystem ecology STEM course. [PDF]
O'Connell CS.
europepmc +1 more source
Analysis of Cancer Research Projects in Sub-Saharan Africa: A Quantitative Perspective on Unmet Needs and Opportunities. [PDF]
Davies L +11 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Research Projects How They Sprout, Bloom, and Wither Away. [PDF]
Hoffmann RW.
europepmc +1 more source
Developing the next generation of renewable energy technologies: an overview of low-TRL EU-funded research projects. [PDF]
Pérez Caballero LM +22 more
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