Results 91 to 100 of about 18,010,417 (271)
Revista de Economia Mackenzie, 2006 The main aim of this paper is to verify whether the world tendency to have the financial capital as the main sponsor of university research is also true in Brazil and the consequences of this move to education and to economic development.
Julia Paranhos +2 more
doaj
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
ORED Communicator - July 2015 [PDF]
, 2015 The July 2015 issue of the Office of Research and Economic Development newsletter.https://digitalcommons.fiu.edu/research_newsletter/1021/thumbnail ...
Office of Economic Research and Development, Florida International University
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
ORED Communicator - June 2015 [PDF]
, 2015 The June 2015 issue of the Office of Research and Economic Development newsletter.https://digitalcommons.fiu.edu/research_newsletter/1020/thumbnail ...
Office of Economic Research and Development, Florida International University
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
ORED Communicator - May 2015 [PDF]
, 2015 The May 2015 issue of the Office of Research and Economic Development newsletter.https://digitalcommons.fiu.edu/research_newsletter/1019/thumbnail ...
Office of Economic Research and Development, Florida International University
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source