Results 171 to 180 of about 14,722,971 (292)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Vaccine equity in Africa: a rapid review of policy, legal and governance frameworks to improve research and development. [PDF]

Front Health Serv
Ataguba JE, Muriithi GN, Achala DM, Adote ENA, Nwosu CO, Beshah SA, Zegeye EA, Yaya Bocoum FIK, Sumboh J, Setshegetso N, Yakhelef N, Muhwava W.   +11 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development. [PDF]

ASAIO J
Arens J, Belliato M, Broman LM, Clauser JC, Donker DW, Lorusso R, Malfertheiner M, Rajsic S, Swol J, Vercaemst L, Prahl Wittberg L, EACTS Innovation Committee, Section CPB, ECLS & MCS and the EuroELSO Innovation Group, EACTS Innovation Committee, Section CPB and ECLS & MCS and the EuroELSO Innovation Group.   +15 more
europepmc   +3 more sources

The impact of the United States most favored nation policies on prices of branded medicines and research and development. [PDF]

Health Policy Open
Epstein D.
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Ebola virus and Sudan virus infection in humans: a comparison to inform vaccine research and development. [PDF]

Emerg Microbes Infect
Whitworth HS, Quintard G, Oyeneye V, Postler TS, Marini A, Zaric M, Fast P, Meller M, Gurrion S, Mutua G, Malkevich N, Heinrichs J, Gupta SB, Francis SC.   +13 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Klebsiella vaccine research and development in Africa: a rapid scoping review of current evidence and future priorities. [PDF]

BMJ Public Health
Iwu-Jaja C, Mazingisa AV, Jaca A, Iwu CD, Wiysonge CS.   +4 more
europepmc   +1 more source

Research by the developed on the developing: View from the “researched”.

The Sociological Review Magazine, 2020
openaire   +1 more source