Results 151 to 160 of about 10,811,602 (304)

Advancing the Science of Patient Input in Drug Research and Development. [PDF]

J Particip Med
Metcalf MA, Osei-Anto HA, Sharpe TJ, Clark LT, Shore CK.   +4 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Better living through research and development: 90th annual report, 1971 [PDF]

, 1971
Ohio Agricultural Research and Development Center
core  

Progress in the research and development of oncolytic virus therapies. [PDF]

Front Pharmacol
Li Y, Qin X, Liang C, Wang L.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Pathways to progress through agricultural research and development: 88th annual report, 1969 [PDF]

, 1969
Ohio Agricultural Research and Development Center
core  

A conceptual matrix model of patient involvement and patient expertise in medicines and medical technology research and development. [PDF]

Res Involv Engagem
Rosenberg A, Bharadia T, Yeoman G, Clark L, McClelland GR.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

New knowledge for a better Ohio through agricultural research and development: 89th annual report, 1970 [PDF]

, 1970
Ohio Agricultural Research and Development Center
core  

Tracking Canada's 2015 vaccine research and development priorities: Where are we a decade later? [PDF]

Can Commun Dis Rep
Moqueet N, Lago K, Cortés-Kaplan S, Birdi H, Desai S, Gauhar A, Warshawsky B, Tunis M, Wilkinson K.   +8 more
europepmc   +1 more source