Results 141 to 150 of about 10,811,602 (304)

RDC review Jan 2004: Bulletin for Research and Development UiTM

open access: yes, 2004
IRDC Review takes a short walk down memory lane to recap on some of the significant issues and events that impacted the Institute in the past year. Indeed it has been a year of achievements at the Institute of Research, Development and Commercialisation (
UiTM, Institute of Research, Development and Commercialization
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Governmental aspects of development in the Bicol Region

open access: yes, 1974
Phase I of a three-part study for the Cooperative Regional Development ProjectThis study is concerned with development in Bicol, focusing on the public sector's approach to development therein. Discusses such components of program formulation as politics,
National Development Research Centre   +1 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

New wealth through agricultural research and development: 86th annual report [PDF]

open access: yes, 1967
Ohio Agricultural Research and Development Center
core  

Two thousand and fourteen [2014] Annual Symposium : Reflections on Priorities for Development Policy Research in Cambodia

open access: yes, 2015
This report summarises the key messages of 30 presentations with implications for research policy and practice under six key themes: economy, agriculture, natural resources, health, education and the ASEAN Economic Community (AEC).
Madhur, Srinivasa
core  

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