Results 221 to 230 of about 19,550,098 (273)

Research and development of new intelligent foaming and discharging agent system. [PDF]

Sci Rep
Zhao S, Fu M, Hou B, Zhang J, Li X.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Priority knowledge gaps for schistosomiasis research and development in the World Health Organization Africa Region. [PDF]

Infect Dis Poverty
Mwinzi PN, Chimbari M, Sylla K, Odiere MR, Midzi N, Ruberanziza E, Mupoyi S, Mazigo HD, Coulibaly JT, Ekpo UF, Sacko M, Njenga SM, Tchuem-Tchuente LA, Gouvras AN, Rollinson D, Garba A, Juma EA.   +16 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Zika virus vaccines and monoclonal antibodies: a priority agenda for research and development. [PDF]

Lancet Infect Dis
Ostrowsky JT, Katzelnick LC, Bourne N, Barrett ADT, Thomas SJ, Diamond MS, Beasley DWC, Harris E, Wilder-Smith A, Leighton T, Mehr AJ, Moua NM, Ulrich AK, Cehovin A, Fay PC, Golding JP, Moore KA, Osterholm MT, Lackritz EM, Zika Expert Workgroup.   +19 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Behavioral Intervention to Prevent HIV/AIDS Among Young Adults Using Motivational Culture-Based Communication: Protocol for a Research and Development Study.

JMIR Res Protoc
Umam MK, Setiawan A, Permatasari H, Mansyur M.   +3 more
europepmc   +1 more source

First Decade of the National Cancer Institute's Affordable Cancer Technologies Program: Accelerating Translational Technology Research and Development for Cancer Globally. [PDF]

JCO Glob Oncol
Pearlman PC, Divi R, Huppi R, Garton E, Kidambi S, Tandon P, Ossandon M, Ginsburg O, Gopal S.   +8 more
europepmc   +1 more source

Epigenetics: rethinking of drug research and development. [PDF]

Future Med Chem
Lundstrom K.
europepmc   +1 more source

Improving research and development of wearable assistive and rehabilitation technologies: a systematic review on diversity factors. [PDF]

J Neuroeng Rehabil
Lorke M, Stefanou T.
europepmc   +1 more source