Results 51 to 60 of about 4,928,766 (307)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Regenerative TherapyThe amended Act on the Safety of Regenerative Medicine (RM Act) in Japan expands its scope to include in vivo gene therapy and related technologies, classifying them into Class I, the highest-risk category.
Satoshi Hosoya +5 more
doaj +1 more source
Scientific Reports, 2017 To assess the accuracy of ultrasound measurements of fetal biometric parameters for prenatal diagnosis of microcephaly in the context of Zika virus (ZIKV) infection, we searched bibliographic databases for studies published until March 3rd, 2016.
Ezinne C. Chibueze +12 more
doaj +1 more source
Urban conservation areas and sustainable development: exploring the relationship [PDF]
, 1998 With increasing emphasis being placed on concentrating development in urban areas and improving the quality of life in British cities and towns, the importance of accommodating necessary development without compromising the valued heritage and ...
Doak, Joe, Lynch, Jane
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Policy Coherence and Social Protection in Ethiopia: Ensuring No One Is Left Behind
Societies, 2019 Ethiopia has made a strong commitment to strengthen its social protection system. However, resource constraints pose significant challenges in seeking to meet the basic needs of all people.
Melisew Dejene Lemma, Logan Cochrane
doaj +1 more source
A Research Agenda for Ending Homelessness [PDF]
, 2007 This Research Agenda was developed in order to better inform government agencies, philanthropic organizations, and other funders about research questions that will help move policy and practice forward.
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FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
The Maritime Potential of ASEAN Economies
Journal of Current Southeast Asian Affairs, 2011 Countries may utilize a long coastline in relation to their landmass as a resource to develop their maritime economy. This paper argues that ASEAN countries differ in utilizing their maritime potential.
Hans-Dieter Evers, Azhari Karim
doaj +1 more source