Results 11 to 20 of about 3,733,869 (258)

Unlocking Innovation: Assessing the Role of Agricultural R&D in Latin America and the Caribbean [PDF]

, 2023
This report presents a comprehensive analysis of public agricultural research and development (R&D) in Latin America and the Caribbean (LAC), focusing on the contextual factors influencing agricultural R&D investment and their implications for ...
Inter-American Development Bank
core   +1 more source

Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery

Journal for ImmunoTherapy of Cancer, 2019
Background The ability to modulate immune-inhibitory pathways using checkpoint blockade antibodies such as αPD-1, αPD-L1, and αCTLA-4 represents a significant breakthrough in cancer therapy in recent years.
Molly A. Taylor, Adina M. Hughes, Josephine Walton, Anna M. L. Coenen-Stass, Lukasz Magiera, Lorraine Mooney, Sigourney Bell, Anna D. Staniszewska, Linda C. Sandin, Simon T. Barry, Amanda Watkins, Larissa S. Carnevalli, Elizabeth L. Hardaker   +12 more
doaj   +1 more source

TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis

Nature Communications, 2022
The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the ...
Kasparas Petkevicius, Henrik Palmgren, Matthew S. Glover, Andrea Ahnmark, Anne-Christine Andréasson, Katja Madeyski-Bengtson, Hiroki Kawana, Erik L. Allman, Delaney Kaper, Martin Uhrbom, Liselotte Andersson, Leif Aasehaug, Johan Forsström, Simonetta Wallin, Ingela Ahlstedt, Renata Leke, Daniel Karlsson, Hernán González-King, Lars Löfgren, Ralf Nilsson, Giovanni Pellegrini, Nozomu Kono, Junken Aoki, Sonja Hess, Grzegorz Sienski, Marc Pilon, Mohammad Bohlooly-Y, Marcello Maresca, Xiao-Rong Peng   +28 more
doaj   +1 more source

Nonadditivity in public and inhouse data: implications for drug design

Journal of Cheminformatics, 2021
Numerous ligand-based drug discovery projects are based on structure-activity relationship (SAR) analysis, such as Free-Wilson (FW) or matched molecular pair (MMP) analysis. Intrinsically they assume linearity and additivity of substituent contributions.
D. Gogishvili, E. Nittinger, C. Margreitter, C. Tyrchan   +3 more
doaj   +1 more source

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Molecular Metabolism, 2022
Objective: Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities.
Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sørensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes   +25 more
doaj   +1 more source

Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator

Respiratory Research, 2020
Background Navafenterol (AZD8871) is an inhaled long-acting dual-pharmacology muscarinic antagonist/β2-adrenoceptor agonist (MABA) in development for the treatment of obstructive airways diseases.
Eulalia Jimenez, Carol Astbury, Muna Albayaty, Ulrika Wählby-Hamrén, Beatriz Seoane, Cristina Villarroel, Helena Pujol, Maria Jesus Bermejo, Ajay Aggarwal, Ioannis Psallidas   +9 more
doaj   +1 more source

Transformer-based molecular optimization beyond matched molecular pairs

Journal of Cheminformatics, 2022
Molecular optimization aims to improve the drug profile of a starting molecule. It is a fundamental problem in drug discovery but challenging due to (i) the requirement of simultaneous optimization of multiple properties and (ii) the large chemical space
Jiazhen He, Eva Nittinger, Christian Tyrchan, Werngard Czechtizky, Atanas Patronov, Esben Jannik Bjerrum, Ola Engkvist   +6 more
doaj   +1 more source

Physical activity end-points in trials of chronic respiratory diseases: summary of evidence

ERJ Open Research, 2022
Background Physical activity contributes to improving respiratory symptoms. However, validated end-points are few, and there is limited consensus about what is a clinically meaningful improvement for patients.
Cassie Rist, Niklas Karlsson, Sofia Necander, Carla A. Da Silva   +3 more
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Buffer evaluation model and scheduling strategy for video streaming services in 5G-powered drone using machine learning

EURASIP Journal on Image and Video Processing, 2021
With regard to video streaming services under wireless networks, how to improve the quality of experience (QoE) has always been a challenging task. Especially after the arrival of the 5G era, more attention has been paid to analyze the experience quality
Yu Su, Shuijie Wang, Qianqian Cheng, Yuhe Qiu   +3 more
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Sheep research and development, 1965 [PDF]

, 1965
Sheep research and development - 1965 / D. S. Bell -- Improvement of lamb meat production through breeding / D. S. Bell, C. F. Parker and L. E. Kunkle -- Breeding performance of Targhee ewes maintained under bluegrass pasture vs. ladino clover pasture vs.
Judy, J. K., Kunkle, L. E., Sanger, V. L., Tyznik, W. J., Johnson, R. R., Davis, D. L., Redman, D. R., Bell, D. S., Parker, C. F., Pounden, W. D., Cline, J. H., Van Keuren, R. W., Trapp, A. L., Hamdy, A. H.   +13 more
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