Results 121 to 130 of about 46,037,565 (314)

Research Collaboration as “Layers of Engagement”: INKE in Year Four

, 2014
Many academic teams and granting agencies undergo a process of reflection at a project’s completion to understand lessons learned and develop best practice guidelines.
Siemens, Lynne, INKE Research Group
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Journey of a Research Article [PDF]

The Journal of Obstetrics and Gynecology of India, 2018
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Treatment effect modifiers of cognitive behaviour therapy in people with psychosis: an individual participant data meta-analysis of RCTs

Health Technology Assessment
Background Cognitive–behavioural therapy is a recommended intervention for the treatment of schizophrenia and related psychoses, but there is considerable uncertainty on whether its effectiveness is moderated by patient characteristics and/or ...
Filippo Varese, Maria Sudell, Anthony P Morrison, Eleanor Longden, Catrin Tudur Smith   +4 more
doaj   +1 more source

ZA'FARON'S COMPONENTS: RESEARCH ARTICLE

Crocus sativus is one of the most valuable spices and natural dyes in the world. Its unique smell, color and taste, as well as its various health benefits, made it a commonly used ingredient in pazandalik and medicine. This article focuses on identifying
D. B. Haydarova
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Role of Extension in a Research University

University administrators are placing greater emphasis on research and extramural funding in an effort to raise their stature among peer institutions. While Extension faculty could feel threatened, they actually have an opportunity to fill the void in ...
Gustafson, Cole R.
core  

Oh, what a tangled web we weave: experiences of doing ‘multiple perspectives’ research in families

, 2010
It is not uncommon to explore the views of parents and children in qualitative research with families. Yet the implications and challenges of a multiple perspective approach often remain at a relatively taken‐for‐granted level. In this article we draw on
Hill, M., Harden, Jeni, Backett‐Milburn, K., MacLean, Alice, Backett-Milburn, Kathryn, Harden, J., Hill, Malcolm, MacLean, A., Backett‐Milburn, Kathryn   +8 more
core   +1 more source