Results 121 to 130 of about 72,787,703 (302)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Arctic Ocean Acidification 2013: An Overview

, 2014
Report presenting a summary of the first comprehensive assessment of Arctic Ocean acidification (AOA) conducted by the Arctic Monitoring and Assessment Programme (AMAP).
Arctic Monitoring and Assessment Programme
core  

Hawaii geothermal assessment program [PDF]

, 1993
"Geophysics subtask: microseismicity survey and imaging of crustal complexity in the Puna geothermal region on the island of Hawaii using the PANDA seismic array and gravity measurements."Hawaii Geothermal Assessment ...
Hawaii Geothermal Assessment Program
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Recent cognitive psychology research shows strongly that quizzes help retain learning. What does this mean for computer-assisted assessment?

, 2012
Recent research in cognitive psychology has deepened understanding of the positive effect of retrieval practice on retention of learning. Studies clearly show that practising retrieval, including taking formative quizzes and tests, is an efficient way of
Kleeman, John
core  

Responses to the critics

Novation
Personal comment on the responses to “Towards a New Ethos of Science or a Reform of the Institution of Science? Merton Revisited and the Prospects of Institutionalizing the Research Values of Openness and Mutual Responsiveness” by René von Schomberg.
René von Schomberg
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Strengthening Research Capability Assessment for Teacher Educators [PDF]

Research capability is essential in higher education institutions, particularly for faculty members who contribute to evidence-based teaching, policy development, and institutional growth.
Calanoga, Marie Claudette, Amanonce, Jay-cen, Tamayo, Ria, Temporal, Conchita, Tamayao, Antonio, Vecaldo, Rudolf, Calubaquib, Jhoanna, Maribel, Maribel   +7 more
core  

Towards a New Ethos of Science or a Reform of the Institution of Science? Merton Revisited and the Prospects of Institutionalizing the Research Values of Openness and Mutual Responsiveness [Special Edition]

Novation
Over the past decade, we have witnessed a gradual and consistent evolution of research practices towards a more open science. This shift has been driven by both internal expectations within the scientific community and external demands from research ...
René von Schomberg
doaj   +1 more source