Results 131 to 140 of about 9,915,672 (306)

Becoming PBRF-able: Research assessment and education in New Zealand [PDF]

, 2009
It seems ironic that, designed as they are to quantify, evaluate and reward the research quantum of academic institutions, departments and individuals, research assessment exercises have themselves become objects of their research and critique.
Middleton, Sue
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

How the Global South is reshaping scholarly communication

eLife
The Global South has emerged as a beacon of innovation in scholarly publishing, championing equitable and community-driven models of knowledge dissemination.
Humberto Debat, Izuchukwu Azuka Okafor, Mercury Shitindo, Olavo B Amaral, Nurul Izzati, Chandana Basu Mallick, Awika O Henry, Roseline Dzekem Dine, Carolina Santacruz-Perez   +8 more
doaj   +1 more source

An assessment of warm fog: Nucleation, control, and recommended research [PDF]

, 1974
A state-of-the-art survey is given of warm fog research which has been performed up to, and including, 1974. Topics covered are nucleation, growth, coalescence, fog structures and visibility, effects of surface films, drop size spectrum, optical ...
Connell, J. R., Corrin, M. L., Gero, A. J.   +2 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Research assessment: A contribution to solving the publication credit allocation problem [PDF]

, 2017
In allocation problems, a given set of goods are assigned to agents in such a way that the social welfare is maximised, that is, the largest possible global worth is achieved.
Schaerf, Marco
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Citation distributions and research evaluations: The impossibility of formulating a universal indicator

Journal of Data and Information Science
To analyze the diversity of citation distributions to publications in different research topics to investigate the accuracy of size-independent, rank-based indicators.
Rodríguez-Navarro Alonso
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Italian Research Assessment Exercises

Italian Political Science, 2018
Italian universities have so far experienced three assessment exercises (2001-3, 2004-10 and 2011-14). The fiscal law approved in December 2016 dictates that from now onwards the reference periods will be quinquennial, reducing the discretionary power so
Daniele Checchi
doaj