Results 131 to 140 of about 4,853,650 (311)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The French HER system and the issue of evaluation

Italian Political Science, 2018
The French higher education and research system is based on a double divide of missions, statuses and recruitment procedures. On one side, over 30 public research organizations – whose permanent scientific staff varies from about 300 to over 12.000 ...
Catherine Paradeise
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Organizing and Financing Basic Research to Increase Food Production [PDF]

, 1977
A report prepared by the Office of Technology Assessment analyzing" alternatives for organizing and financing basic research to increase food production" (Preface)
United States. Congress. Office of Technology Assessment.
core  

Development and validation for research assessment of Oncotype DX® Breast Recurrence Score, EndoPredict® and Prosigna®. [PDF]

NPJ Breast Cancer, 2021
Buus R, Szijgyarto Z, Schuster EF, Xiao H, Haynes BP, Sestak I, Cuzick J, Paré L, Seguí E, Chic N, Prat A, Dowsett M, Cheang MCU.   +12 more
europepmc   +1 more source

Assessing research quality [PDF]

Nature Immunology, 2006
openaire   +2 more sources

Grand Challenges in Measuring and Characterizing Scholarly Impact

Frontiers in Research Metrics and Analytics, 2016
Chaomei Chen
doaj   +1 more source

C-PRISM: Complexity-informed profile for research impact and scholarly merit

Journal of Family Medicine and Primary Care
The h-index, despite widespread adoption, inadequately captures the multidimensional nature of scholarly contribution, conflating productivity with impact while ignoring leadership, independence, research integrity, and collaboration quality.
Sunil Kumar Raina, Raman Kumar, Kanica Kaushal   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Status of Biomedical Research and Related Technology for Tropical Diseases [PDF]

, 1985
A report by the Office of Technology Assessment (OTA) examining the "status of biomedical research and technologies for controlling tropical diseases" (p. iii)
United States. Congress. Office of Technology Assessment.
core