Results 141 to 150 of about 5,314,689 (330)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Co-production and co-creation using self-service technology: the application of service-dominant logic

, 2008
Research on how customers engage in the co-creation processes envisaged by the Servicedominant logic paradigm is currently limited and even less work has been published on frameworks for organizations to manage the co-creation process.
Hilton, T., Hughes, T.
core  

A Co‐production Evaluation Tool Informed by Co‐production Workshops for Use in Evidence Synthesis Contexts

Cochrane Evidence Synthesis and Methods
Aim We aimed to co‐produce a tool for evaluating co‐production within evidence syntheses. Background Participatory approaches are recommended to enhance the salience and quality of evidence syntheses, and there is an increasing onus on co‐producing ...
Meena Khatwa, Vanessa Bennett, Rachael C. Edwards, Lisa Richardson, Phuong Tu Nguyen, Sajid Saleem, Sylvia Chaires, Alison O'Mara‐Eves, Dylan Kneale   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multicultural Co-production: the Amar Bari, Amar Jibon (My Home, My Life) partnership

In this blog the team behind the “Amar Bari Amar Jibon” (My Home, My Life) research study, share insights and reflections on how to do effective co-production in a multicultural ...
Deepak Gopinath, Manik, Khan, Leena, Uddin, Bashir, Porteus, Jeremy, Ruby, Mahera, Holland, Caroline, Peace, Sheila   +6 more
core  

Inclusivity, Capacity‐Building, Trust, and Respect: An Introduction to the Special Issue Equity in Co‐Production

Community Science
Co‐production is becoming an increasingly important approach to facilitating integrated climate, environmental, social and earth systems research to achieve societal impact.
Kristin M. F. Timm, K. L. Akerlof, Thomas F. Thornton, Jylana L. Sheats   +3 more
doaj   +1 more source

Collaborative Innovation in Public Administration: Theoretical Background and Research Trends of Co-Production and Co-Creation

, 2019
This paper presents the results of the content analysis of 139 Web of Science papers focused on collaborative innovation with external stakeholders of public administration, specifically on co-production and co-creation.
Tina Jukic, Primož Pevcin, Jože Benčina, M. Dečman, Sanja Vrbek   +4 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mondragon Co-operatives - Myth or Model [PDF]

, 1982
Co-operatives Research Unit
core   +1 more source