Results 131 to 140 of about 5,314,689 (330)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Gas Content and Gas Occurrence Mechanism of Deep Coal Seams in the Shenfu-Linxing Block

Energies
The Shenfu-Linxing block in the Ordos Basin holds abundant deep coalbed methane (CBM) resources, which can alleviate gas shortages and aid dual carbon target achievement. Considering isothermal adsorption traits and parameters like vitrinite reflectance,
Litao Ma, Fan Yang, Jianghao Yang, Yi Cui, Wei Wang, Cheng Liu, Bo Zhang, Jiang Yang, Shu Tao   +8 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A realist evaluation of a collaborative model to support research co-production in long-term care settings in England: the ExCHANGE protocol. [PDF]

Res Involv Engagem, 2021
Wilkinson K, Day J, Thompson-Coon J, Goodwin V, Liabo K, Coxon G, Cox G, Marriott C, Lang IA.   +8 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Avert collapse of research co-production systems [PDF]

Nature, 2019
Maria, Kernecker, Maria, Busse, Jana, Zscheischler   +2 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Prenatal diagnosis [Elektronisk resurs] : The co-production of knowledge and values in medical research and public debate

, 2020
This chapter examines how prenatal diagnosis was discussed and interpreted when translated from laboratories and clinics into the public arena. It focusses on debates about policy and regulation in the early 1980s. Drawing on the concept of co-production
Tunlid, Anna,, Lund University.
core   +1 more source

What Do We Know About Sharing Power in Co‐Production in Mental Health Research? A Systematic Review and Thematic Synthesis

Health Expectations
Background Guidance on co‐production between researchers and people with lived experience was published in 2018 by the National Institute for Health and Care Research (NIHR) advisory group, previously known as INVOLVE.
India Hopkins, Max Verlander, Lucy Clarkson, Pamela Jacobsen   +3 more
doaj   +1 more source