Results 121 to 130 of about 5,314,689 (330)
A model for co-production of knowledge: Creating a Research Forum [Elektronisk resurs]
, 2021 Collaborations based on academic–practitioner interactions are not always as straightforward as presented in commonplace transdisciplinary theory. This chapter provides the most important insights from past and ongoing work from a sustainability project ...
Dymitrow, Mirek, +2 more
core
The emerging institutionalisation of knowledge co-production in sustainability research
AmbioAbstract Co-production of knowledge in science-policy interfaces has received increased attention as a way of addressing grand societal challenges with the hope that it will create a base for enacting transformative change. We explore the development and outputs of projects funded by the Strategic Research Council of Finland, which has had ...
Janina Käyhkö +3 more
openaire +3 more sources
Health Expectations, 2019 This paper explores the methodological aspects of a user‐led study investigating mental health service user experiences of targeted violence and abuse (often called 'hate crime').
A. Faulkner +7 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
What types of problems are grand challenges?
Journal of Responsible InnovationThe notion of grand challenges has featured in research policy for over two decades, specifically in the design of funding for societally significant research topics.
Anita Välikangas
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Recruiting and retaining community researchers for a historical research project
Research for All, 2022 This article explores how we recruited and retained a diverse group of community researchers from groups who faced barriers to engaging with research.
doaj +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source