Results 31 to 40 of about 67,114,416 (300)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

“Research” in Community-Partnered, Participatory Research [PDF]

JAMA, 2009
In many underserved communities, research is a loaded word that sets expectations of being examined or exploited.1, 2 This is more likely when data are published but not otherwise shared, such as in a community forum. Research, whether intended or not, may disadvantage groups through highlighting problems and not assets.
Kenneth, Wells, Loretta, Jones
openaire   +2 more sources

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Low-complexity beam-domain channel estimation and power allocation in hybrid architecture massive MIMO systems

EURASIP Journal on Wireless Communications and Networking, 2019
In this journal, we investigate the beam-domain channel estimation and power allocation in hybrid architecture massive multiple-input and multiple-output (MIMO) communication systems.
Xiao Chen, Zaichen Zhang, Liang Wu, Jian Dang   +3 more
doaj   +1 more source

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

Arthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen, Yasuo Nagafuchi, Kristina Lend, Seyam Alemyar, Herman Kasper Glas, Gerdur Gröndal, Bjorn Gudbjornsson, Espen A. Haavardsholm, Kim Hørslev Petersen, Jon Lampa, Merete Lund Hetland, Dan Nordström, Mike Nurmohamed, Mikkel Østergaard, Anna Rudin, Marte Schrumpf Heiberg, Tuulikki Sokka‐Isler, Till Uhlig, Josien Veris‐van Dieren, Ronald van Vollenhoven, Tom Huizinga, Marcel JT Reinders, Sytske Anne Bergstra, Erik van den Akker, Rachel Knevel   +24 more
wiley   +1 more source

Facilitating Community Participants' Research Engagement: Community Members' Perceptions of Community-based Research [PDF]

International Journal of Nursing & Clinical Practices, 2015
To describe the perspectives of community participants about engaging in community-based participatory research, and then to use the information to develop a model to depict the community participants' perceptions of interfacing with academic researchers.A diverse group of Native Hawaiian community-dwelling participants engaged in open-ended and semi ...
Tse, Alice M., Palakiko, Donna-Marie, Daniggelis, Ephrosine, Makahi, Emily   +3 more
openaire   +2 more sources

Generative AI in clinical practice: how should rheumatologists evaluate and monitor emerging tools?

Arthritis Care &Research, Accepted Article.
Generative artificial intelligence (AI) is increasingly being used in rheumatology practice, to assist with tasks such as documentation, record summarization, and clinical decision support. Rheumatologists need a practical approach to determining what evidence and oversight each application requires.
Koushan Kouranloo, Mrinalini Dey, Jinoos Yazdany   +2 more
wiley   +1 more source

Near Optimal Timing and Frequency Offset Estimation for 5G Integrated LEO Satellite Communication System

IEEE Access, 2019
The integration of satellite and terrestrial 5G networks aims to provide ubiquitous coverage, improve service reliability, and enable the network scalability.
Wenjin Wang, Yushan Tong, Lingxuan Li, An-An Lu, Li You, Xiqi Gao   +5 more
doaj   +1 more source

Optical Wireless Communications: Research Challenges for MAC Layer

IEEE Access, 2022
Optical wireless communication (OWC) has emerged as a potential addition to current wireless technologies because of its high capacity, security, and unlicensed spectrum.
Monica Bhutani, Brejesh Lall, Monika Agrawal   +2 more
doaj   +1 more source