Results 31 to 40 of about 51,586,577 (251)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
STRUCTURAL AND COMPONENT ORGANIZATION OF THE RESEARCH COMPETENCE OF A FUTURE MANAGER: MANAGERIAL CONTEXT [PDF]
Alfred Nobel University Journal of Pedagogy and PsychologyThe aim of this article is to provide a comprehensive theoretical and methodological substantiation of the essence, structural content, and development mechanisms of the research competence of a future manager within the rapidly evolving context of ...
Dmytro Zhuravlov
doaj +1 more source
Nordic Journal of Comparative and International Education, 2020 This study contributes to the conceptualisation of teachers’ competence through a systematic review (a concept synthesis) of three key transdisciplinary competencies—teachers’ diversity competence, teachers’ research and development competence, and ...
Bjørn Smestad, Astrid Gillespie
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Образование и наука, 2012 The paper is devoted to developing the research competence in the process of student multilevel training. Upgrading the student’s ability for research ac- tivity is an important task of higher education that should be continually emphasized at all levels.
S. N. Lukashenko
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Problems with competence assessment as it applies to student nurses [PDF]
, 2012 Nursing has enthusiastically embraced the concept of continuing competence as the key means of reassuring the public of the overall quality of the profession.
Gallagher, Peter +2 more
core +1 more source
Foreign language reading competence development via hypertexts
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2023 Importance. Nowadays most interactions with texts take place on the Internet. Because of this, it is required to implement the properties of hypertextuality for education materials creation in order to develop relevant reading skills.
M. I. Dolzhenkova +2 more
doaj +1 more source